Category: Nutraceuticals

Smiling woman looking at a Basil plant

Some Amazing Herbs for Grounding

Posted on by Michael Brown
Smiling woman looking at a Basil plant

Many of us have heard of grounding but may not fully understand what the term means or how to implement it into our daily life.

This post will help you discover the transformative effects of incorporating herbs for grounding into your daily routine. 

With busy schedules, different commitments, and daily stressors, we often forget to care for ourselves by being mindful of what our body needs. In addition, anxiety can be a common problem at any age. The grounding process can help us all return to a calm and relaxed state. 

The process of grounding serves as a means to reestablish a profound connection with our energy centers, commonly known as Chakras. These Chakras comprise seven primary centers. 

The Root Chakra, positioned at the base of the spine, plays a pivotal role in instilling a sense of grounding and security within us. It serves as a conduit linking us to the Earth, providing sustenance for our survival and facilitating the release of bodily toxins.

 The Root Chakra exerts influence over various bodily systems, including the circulatory, urinary/excretory, and reproductive systems, as well as the legs, bones, and teeth. Additionally, it impacts the nose and olfactory system, enhancing stability and physical energy.

Young Lady Daydreaming

Some of the signs that you have an imbalanced root center are:

  • Excessive daydreaming.
  • A lack of fulfillment and satisfaction.
  • Allowing harmful or destructive emotions to influence your behavior, such as addictive behaviors.
  • Unhealthy codependent relationships.
A mortal and pestle along with Lavendar flowers

Plants have a grounding effect and can be a cornerstone of optimal health. Plants are a natural gift. An herb garden can be the best option for creating your high-quality herbal superstars. You can create your own blend of aromatic herbs. 

Lavender flowers, for example, can be used in teas or oils for a calming effect. Even the aroma of dried lavender in a tea bag can reduce stress. 

In times of uncertainty, plants possess a remarkable capacity to provide healing and solace. They serve as a poignant reminder that we are eternally connected to a larger existence. 

With their roots firmly anchored in the Earth, plants embody the essence of being truly grounded. Their roots mean they are quite literally ‘grounded’ in the Earth.

During times of uncertainty and hopelessness, many strategies can help us be present and work through these feelings, such as meditation. 

Meditation allows us to ease the tension in our lives. Meditation is one technique that is often used for stress management and helps to alleviate mental fog. Journaling, another option, allows us to process our feelings in written form. 

Additionally, dance or yoga allow us to express our feelings and work through our emotions.

One vital connection to make is to understand that self-love may involve getting rid of toxic relationships in your life. Taking responsibility for yourself and keeping peace with past issues or people are other ways to balance your root chakra.

Girl holding cup of herbal tea

Indulging in the soothing ritual of sipping herbal tea offers a splendid avenue to achieve tranquility and a sense of groundedness. Beyond being a means to embrace the present moment, an herbal infusion holds the potential to bestow medicinal benefits that bolster overall well-being and fortify the immune system. 

To enhance absorption, the inclusion of black pepper in the herbal tea proves beneficial. This delightful practice allows one to relish a myriad of potent, curative, and calming properties found within herbal remedies. 

When preparing, the dosage may vary for different herbs, but as a general guideline, placing one tablespoon of dried herbs (or two tablespoons of fresh herbs) in a tea ball, tea bag, or strainer and immersing it in a cup of hot water is recommended.

 Allowing the herbs to steep for up to ten minutes, depending on the desired potency of the herbal tea, is advised. It’s worth noting that steeping for too long may result in a slightly bitter taste.

Medicinal herbs

Some beneficial organic herbs are listed below. Each of the dried herbs works in a different way.

Ashwagandha is known for its rejuvenating effects on the nervous system. It can help with stress and anxiety and is good for heart health.

Holy Basil is a wonderful herb for the nervous system. It encourages flow and can help move thought into action. It is also supportive of the immune system and helps to nourish the stress response system to be more resilient.

Within Green Tea, there exists an amino acid called Theanine, which guides caffeine towards cognitive pathways, amplifying mental clarity without inducing jittery sensations.

Turmeric is an anti-inflammatory. Turmeric can be both comforting and invigorating at the same time. 

Yarrow is helpful in fighting infections .

Kava lends its remarkable properties to promote relaxation of both the mind and body. This extraordinary herb proves beneficial in alleviating stress, anxiety, and insomnia, offering relief from these common afflictions.

Oregano and Thyme are nutrient-dense and full of essential vitamins and minerals.

Rosemary is packed with nutrients and is very soothing for the body.

Cinnamon and Ginger help with digestion, soothe nerves and pain, and help to ward off bacteria and viruses.

Chamomile is regarded as one of the most widely favored herbs for inducing relaxation and holds a prominent position among herbal enthusiasts.

Sage is good for the brain. It quickens the senses and aids in memory.

Damiana possesses remarkable qualities that promote a sense of calm and invigoration within the gastrointestinal (GI) tract. Simultaneously, it serves as an uplifting agent for the spirit while stimulating circulation, particularly in the pelvic region.

Among herbalists, lavender holds a special place as an all-time favorite herb for alleviating difficult emotions. Its remarkable ability to soothe the nervous system offers a calming effect, serving as a grounding force for both the body and the senses during periods of heightened stress.

Passionflower is a calming herb, but it has also been used topically to treat boils, wounds, and earaches. 

Ginseng is thought to help boost cognitive functions that improve memory and elevate mood.

Lemon balm dates back to the Middle Ages. Lemon balm is used to promote sleep, ease tension, settle digestive discomfort, and improve appetite. 

Incorporating herbal supplements into one’s routine presents an additional avenue to bolster cognitive functions, enhance the digestive system, and furnish the body with vital nutrients.

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Beet Smoothie

As mentioned previously, good nutrition is extremely important and grounding. 

Beets are an example of a food that replenishes your body and offers many benefits to your overall health. Beets are a deep magenta root vegetable high in Vitamin C, fiber, and essential nutrients like potassium and manganese. 

Beets are known to boost stamina, and help detoxify the body (especially the liver, which is associated with emotional holdings of stress, anxiety, and depression). Beets also lower blood pressure. 

Below is a recipe from Maui Medicinal Herbs of a beet smoothie bowl you may want to try. The ingredients are all blended together and then topped with one or more of the optional garnishes.

INGREDIENTS

  • 1 cup frozen or fresh blueberries
  • 1/2 cup raw red beets, diced small {approximately 1 medium-sized beet}
  • 2 small apple bananas
  • 1/4 cup coconut
  • 2 handfuls Kale
  • 10 mint leaves – adds a nice cooling effect
  • 2 chunks of peppermint chocolate
  • 3/4 cup almond or coconut milk
  • 1 tablespoon kava powder

OPTIONAL GARNISHES:

  • Hemp seeds
  • Bee Pollen
  • Fresh Berries
  • Frozen banana slices
  • Coconut chunks
  • Honey or maple syrup
  • Lilikoi
  • Gluten-Free Granola

By integrating herbal medicine, culinary herbs, essential oils, improved nutrition, or meditation into your daily routine, you invite the infusion of nature’s essence and positive energy into your human realm, leading to multifaceted benefits. 

There exists a profound enchantment when we embrace the stress-relieving attributes of aromatic plants and incredible greens. 

Taking inspiration from Native Americans, it becomes evident that potent herbs hold tremendous medicinal potential. Embracing these practices empowers us to harness the remarkable healing power of nature.

Michael Brown in Lab Coat with arms crossed

Michael J. Brown, RPh, BCPS, BCPP

Mr. Brown is a Clinical Pharmacist specializing in pharmacotherapy and psychiatry.

Read Michael’s story here.

Feel free to send Michael a message using this link.

 
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9 Best Herbs For Focus

Posted on by Michael Brown
herbs in a mortal and pestal

Are you looking for something to improve your concentration?

 Do you want increased energy levels and mental clarity? 

This post will review several herbal supplements that can improve brain function, boost energy levels, and enhance cognitive performance.

Lemon Balm

Lemon Balm

Lemon balm (Melissa officinalis) is an herb that has been used for centuries to promote calmness, reduce stress and anxiety, and improve cognitive function. Some studies suggest that it may help improve focus and concentration.

A study published in the journal “Nutrients” found that lemon balm extract improved cognitive performance and mood in healthy young adults. The researchers attributed these effects to the herb’s ability to modulate neurotransmitters, including acetylcholine, which is involved in learning and memory.1

Lemon balm, in combination with valerian root, passionflower, and butterbur extracts (Ze 185), has been shown to decrease the need for benzodiazepines in some patients.2

 These studies suggest that it may be a useful natural remedy for improving cognitive function and reducing stress and anxiety. 

Ginkgo Biloba

Ginkgo Biloba

Like lemon balm, Ginkgo Biloba has a variety of health benefits. It is a powerful antioxidant that can decrease oxidative stress by neutralizing free radicals. One study published in 2002 showed Ginkgo Biloba may enhance memory in healthy individuals 60 years of age and older.3

Another study showed Ginkgo Biloba was effective in improving mental status scores in patients with Alzheimer’s disease and mild cognitive impairment.4

It is important to note that not all studies have confirmed these findings. 

Ginko Biloba is a very popular natural herb, and in the book “Rosemary Gladstar’s Herbs for Longevity and Well-Being,” it is named as her number one herb of longevity.

Gotu Kola

Gotu Kola

Gotu Kola is an herb related to parsley. This ayurvedic herb has been used for wound healing, circulation, and burns. 

Gotu kola (Centella Asiatica) is an herb that has been traditionally used in Ayurvedic medicine to improve cognitive function, memory, and concentration. Some studies have investigated the effects of gotu kola on focus and concentration.

One study found that a combination of gotu kola and Bacopa monnieri (another herb traditionally used for cognitive enhancement) improved cognitive function, attention, and working memory in healthy adults.5

An article in Trends in Food Science & Technology concluded  C. asiatica can be neuroprotective and targets multiple disease pathways to fight neurodegenerative disorders.6

Ashwagandha

Ashwagandha (Withania somnifera) is an adaptogenic herb that has been routinely used in Ayurvedic medicine to improve cognitive function, including memory, concentration, and mental focus. Some studies have investigated the effects of ashwagandha on mental focus.


One study published in the Journal of Dietary Supplements found that ashwagandha root extract improved cognitive function, including attention and information processing speed, in healthy adults.7

A separate study found Ashwagandha can enhance memory, reduce brain aging and stress.8

A review of several studies published in the Journal of Traditional and Complementary Medicine found ashwagandha has potential as a natural cognitive enhancer, particularly for improving memory and attention.9

Bacopa Monnieri

Bacopa monnieri is an herb traditionally used in Ayurvedic medicine to enhance cognitive function, including memory and focus. Several studies have investigated the effects of Bacopa monnieri on focus and concentration.

One study published in the Journal of Alternative and Complementary Medicine found that Bacopa monnieri improved cognitive function and processing speed in healthy older adults.10

 Another study published in the Journal of Psychopharmacology found that Bacopa monnieri improved memory consolidation and attention in healthy adults. This study also showed Bacopa has an anxiolytic effect as well.11

A review of several studies published in the Journal of Ethnopharmacology concluded that Bacopa monnieri has potential as a cognitive enhancer, particularly for improving memory and attention.

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Green Tea

Green Tea

Green tea is a popular beverage that contains a variety of compounds, including caffeine and L-theanine, that may have cognitive-enhancing effects.

One study published in Phytomedicine found that green tea improved memory, attention, and brain function.12

Another study found that higher consumption of green tea is associated with a lower incidence of cognitive impairment in humans.13

More research is needed to grasp the effects of green tea on focus and concentration. These studies suggest that the combination of caffeine and L-theanine in green tea may have cognitive-enhancing benefits. It’s important to note that green tea and its extracts do contain caffeine, which can have side effects like jitteriness, insomnia, and increased heart rate, especially in high doses or in individuals who are sensitive to caffeine.

Asian Ginseng

Asian Ginseng

Asian ginseng (Panax ginseng) is an herb that has been traditionally used in Chinese medicine to enhance cognitive function, including memory, concentration, and mental clarity. Some studies have investigated the effects of Asian ginseng on mental focus.

One study published in the Journal of Psychopharmacology found that a single dose of Asian ginseng improved cognitive performance, including attention, working memory, and reaction time, in healthy young adults.14

Another study published in the journal Phytotherapy Research found that daily supplementation with Asian ginseng extract improved cognitive function and mood in middle-aged adults with age-related cognitive decline.15

A review of several studies published in the Journal of Ginseng Research concluded that Asian ginseng has potential as a natural cognitive enhancer, particularly for improving attention and cognitive processing speed.16

While Asian ginseng appears to have promising effects on mental focus, more research is needed to fully understand its benefits and optimal dosages.

Rhodiola rosea

Rhodiola Rosea

Rhodiola rosea is an herb that has been traditionally used in Russia and Scandinavia to improve physical and mental performance, reduce fatigue, and enhance mood. In addition, some studies have investigated the effects of Rhodiola rosea on focus and concentration.

One study published in Molecules stated Rhodiola is effective in treating stress-related conditions and disorders.17

Another study published in the Journal of Psychopharmacology found that Rhodiola rosea extract improved cognitive function and reduced mental fatigue in physicians working night shifts.18

A review of several studies published in the Journal of Alternative and Complementary Medicine concluded that Rhodiola rosea has the potential as a natural cognitive enhancer, particularly for improving mental fatigue and stress-related cognitive dysfunction.

Holy Basil

Holy Basil

Holy basil (Ocimum tenuiflorum), also known as tulsi, is an herb that has been commonly used in Ayurvedic medicine to enhance cognitive function and reduce stress and anxiety. Some studies have investigated the effects of holy basil on focus and concentration.

One study published in the International Journal of Ayurveda Research found that holy basil extract improved cognitive function, including attention, memory, and executive function, in healthy adults.
Another study from the Journal of Ayurveda and Integrative Medicine found that holy basil extract improved cognitive function and reduced stress in healthy older adults.19

A review of several studies published in the Evidence-Based Complementary and Alternative Medicine Journal showed those who consumed Holy Basil had a positive change in mood and/or cognitive function regardless of age, gender, formulation, dose, or study quality.20

pharmacist Michael

If you are having trouble concentrating, the first step is to be sure you are eating a healthy diet and getting enough sleep. Exercise can also help. 

Medicinal herbs can be a good choice as well. I suggest finding a popular herbal blend such as Brain & Focus by Sunshine Nutraceuticals. 

This product is specially designed to improve memory and focus by utilizing vitamins, minerals, and natural herbs. It is crucial to take care of your physical and cognitive health. 

Always remember that just because some of these herbal remedies listed do not have robust clinical studies to support them, that does not mean they are ineffective. Clinical trials are expensive, and drug companies are unwilling to spend money on them if they cannot get a good return on their investment.

Michael Brown in Lab Coat with arms crossed

Michael J. Brown, RPh, BCPS, BCPP

Mr. Brown is a Clinical Pharmacist specializing in pharmacotherapy and psychiatry.

Read Michael’s story here.

Feel free to send Michael a message using this link.

 
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Picture of seas moss growing on rocks

Is Sea Moss Good for Acid Reflux and Other Medical Conditions?

Posted on by Michael Brown
Picture of seas moss growing on rocks

Is sea moss good for acid reflux?
What are some other health benefits of sea moss supplements?

 

Sea moss (Chondrus crispus), also known as Irish moss, due to its red color, is an edible plant that grows in tidepools in both the Atlantic and Pacific oceans. Sea moss isn’t a moss but a type of algae or seaweed. For this reason, sea moss is also known as red algae. This plant has a rich nutrient profile and is full of essential nutrients.

Disclosure:  This post may contain affiliate links, meaning, at no additional cost to you, I may earn a commission if you click on, or make a purchase through a third-party link.

Sea Moss and Gastroesophageal Reflux Disease (GERD)

I attended pharmacy school between 1985-1988 at Oregon State University in Corvallis, Oregon. I remember one lecture where the professor poured an acidic solution into a beaker and added Gaviscon liquid. The Gaviscon floated to the top and created a barrier. This demonstration showed how Gaviscon could protect against GERD.

GERD is a common medical condition worldwide. See the diagram below. The United States population is especially prone to this disease.

Global distribution of the burden of gastro-oesophageal reflux disease. Sample-size weighted mean estimates of the prevalence of at least weekly heartburn and/or regurgitation in each country.1

Common GERD symptoms include:

  • Heartburn: Especially after eating or at night
  • Poor Sleep: Pain and discomfort causes night awakenings
  • Trouble swallowing
  • Chest pain
  • Belching
  • Vomiting

GERD can result in decreased work productivity and negatively impact the patient’s quality of life.2

GERD is also a risk factor for throat cancer and Barrett’s esophagus.3

What does this have to do with Sea Moss?

Gaviscon contains sodium alginate, which is also found in sea moss. Sodium alginate can form a barrier between the stomach and the esophagus, protecting the esophagus from stomach acid. Typically, the top portion of the stomach has a valve-like sphincter (lower esophageal sphincter) that closes, protecting the esophagus from the acid found in the stomach. However, when this “valve” doesn’t completely close, stomach acid can leak into the esophagus, causing the pain we know as heartburn and the other symptoms listed above.

One way to treat heartburn is to form a barrier between the stomach and the esophagus: Gaviscon or sea moss can accomplish this. In addition, I always use nutritional supplements over OTC medications or prescription drugs whenever possible.

Sea Moss and Weight Loss

We have talked about weight management in previous posts. Lifestyle changes, exercise, whole foods, adequate sleep, and water intake all help keep our weight in check. Sea moss contains fiber which makes us feel full. If we aren’t hungry, we tend to eat less. Less food equals fewer calories. We all know that controlling our weight is good for our overall health.

man holding stomach in pain

Sea Moss and Digestive Health

Sea moss can help improve gut health. We can use it as a prebiotic. Prebiotics are substances that feed gut bacteria. To read more about the importance of bacteria in the gastrointestinal tract, read “Probiotics, Gut-Brain Axis and Psychiatry.”

Irish moss is also high in fiber which can increase bulk in the gut and help relieve constipation and promote regular healthy bowel movements. The gentle laxative effect of sea moss provides a natural remedy for constipation. Sea moss can also help detoxify the body by removing heavy metals and toxins from the GI tract.

Red seaweed may also help relieve gas and bloating. For example, a study published in March of 2021 found the supplementation of red seaweed in cows reduced enteric methane production by more than 80%.4

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graphic representation of thyroid gland in neck

Sea Moss May Help Some Thyroid Disorders

Our thyroid gland, located in the neck, is responsible for producing thyroid hormones (T3 and T4). Iodine is a trace element not produced by the human body and is necessary to make these thyroid hormones. T3 and T4 are essential to promote growth and brain development in children and help regulate metabolism in adults.5

Hypothyroidism is present in about 5% of Americans aged 12 years and older.6

Hypothyroidism has many causes, including Hashimoto’s Disease (an autoimmune disorder), surgical removal of thyroid gland tissue, radiation treatment with I-131, some medications, and iodine deficiency.

Symptoms of hypothyroidism include:

  • Fatigue
  • Weight Gain
  • Thinning Hair
  • Depressed Mood
  • Dry Skin
  • Muscle Pain
  • Sensitivity to Cold
  • Goiter (Swollen thyroid gland

Irish moss has a high iodine content and can help relieve some thyroid conditions such as hypothyroidism. However, it is important to follow dosing recommendations to avoid ingesting too much iodine.7

Sea Moss and Nutrition

Sea moss is packed with vitamins and essential minerals. The rich zinc content of Irish moss and vitamin A, vitamin C, vitamin E, selenium, and folate can help support the immune system. In addition, sea moss has b vitamins to help increase energy levels and contains antioxidants that may reduce oxidative stress at the cellular level. Sea moss also contains vitamin k, which helps blood clotting and helps build strong bones. Irish moss is also a rich iron source. Iron is vital for red blood cell production, is essential for a healthy pregnancy, and can improve athletic performance.8

Sea moss has many health benefits. This edible plant can help relieve the symptoms of acid reflux and is an excellent digestive aid. It can help with weight loss by creating a feeling of fullness due to its fiber content. Irish moss is a prebiotic that helps feed bacteria in the gut, promoting a healthy digestive system. Thyroid issues resulting from a lack of iodine can also be helped by consuming sea moss. Sticking to the recommended dosage is essential because too much iodine can also be detrimental to health.

Sea moss is a nutritious food containing many essential vitamins and minerals. It has fewer side effects than OTC or prescription drugs. Irish moss is also high in antioxidants.

Sunshine Nutraceuticals has recently added sea moss to our product line. Our supplement contains 500mg Organic Irish Moss, 500mg Organic Bladderwrack, 400mg Organic Burdock and 5mg BioPerine per serving (2 capsules).

If you have any questions about sea moss or any other nutraceutical supplement, feel free to contact me. My contact information is available in the author box below.

Michael Brown in Lab Coat with arms crossed

Michael J. Brown, RPh, BCPS, BCPP

Mr. Brown is a Clinical Pharmacist specializing in pharmacotherapy and psychiatry.

Read Michael’s story here.

Feel free to send Michael a message using this link.

 
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Health Benefits of Green Tea and Honey

Health Benefits of Green Tea and Honey

Posted on by Michael Brown
Green tea and honey

Are you looking for a healthy, great-tasting beverage that is good for your body? 

We all know the benefits of drinking water, but sometimes you need something different. 

What if I told you there is a drink that can lower cholesterol levels, help fight free radicals, help you with weight loss, and even strengthen your immune system? 

This post will explain some of the health benefits of green tea and honey. Green tea can have a bitter taste, and adding honey can make the tea more palatable while adding some health benefits.

Here are a few reasons to consume green tea and honey.

Doctor taking Blood Pressure Reading

May Lower Blood Pressure and Improve Lipid Profiles

Studies have shown that the consumption of green tea can be beneficial to cardiovascular health. A systematic review of twenty random controlled trials including 1536 subjects found green tea intake significantly reduces systolic blood pressure, LDL cholesterol (bad cholesterol), and total cholesterol.1

Another study also found that the administration of green tea lowered both total cholesterol and LDL-cholesterol concentrations. However, no effect on HD cholesterol (good cholesterol) levels was observed in this study.2

Reducing high blood pressure and improving lipid profiles may lower the risk of cardiovascular disease and heart attacks.

Cancer cells

May Have a Role in Cancer Prevention

Several polyphenols are present in green tea leaves, and these compounds are thought to be responsible for their cancer preventative effects. Green tea has the highest polyphenol concentration compared to other teas, which may explain why it is more effective in causing cancer cell damage and death.3

Studies have shown that consumption of green tea can either induce oxidative stress, leading to cancer cell death, or it can act as an antioxidant, preventing cellular damage.4

May Aid in Weight Loss

Green tea extract is a component in many weight loss formulations, including those available at Sunshine Nutraceuticals. For example, in one study, 60 obese subjects (BMI>25) were split into two groups. In addition to their meals, one group was given green tea, and the other group a placebo. The green tea group had significantly higher weight loss than the placebo group at the eight and twelve-week measurements.5

Another study involving 192 moderately overweight Chinese males and females showed that regular consumption of a very-high catechin green tea over 90 days leads to significant reductions in body weight, waist circumference, and intra-abdominal fat.6

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Green Tea and Brain Health

We are learning more about Parkinson’s Disease and dementia each day. The catechins present in green tea are potent antioxidants. They may help protect our brain neurons by scavenging free radicals and chelating iron, activating specific signaling pathways and genes.7

Benefits of Caffeinated Green Tea

Caffeine is the most popular nootropic substance currently in use. We all know how caffeine can boost energy levels and focus. Caffeine can also improve your brain reaction time and exercise performance and may improve cardiac health. However, caffeine is a drug, and no medication is free from side effects. 

For example, too much caffeine can make a person jittery. Caffeine can also be habit-forming and can cause headaches if abruptly discontinued. It can also cause anxiety, especially at higher doses. If you start to feel some of these side effects, try to consume less caffeine. Caffeine may also interact with some medications, so check with your doctor or pharmacist.

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Honey

We all know that honey is a natural sweetener with a yummy taste. But, do you realize that honey has many benefits other than helping soothe a sore throat? 

Always remember that raw honey is a better alternative than processed honey. I know some don’t believe this to be true, but in my opinion, raw honey is a better option. So, what are some of the benefits of raw honey?

doctor with holographic brain between his hands

Honey Also Has Antioxidant Properties and
Positive Effects on the Brain

The brain is especially prone to oxidative damage due to its high oxygen consumption and the presence of polyunsaturated fatty acids found in the neural membranes. Raw honey contains polyphenols which can help protect against fat oxidation. These compounds may also improve learning ability, memory, and cognitive function.

We know that raw honey can help with anxiety and depression and may act as an anticonvulsant.8

Honey Maybe Better in Controlling Blood Sugar Levels
and Preventing Metabolic Syndrome

Honey has been shown to lower blood pressure, decrease obesity, reduce lipid levels, and positively affect diabetes. In addition, honey can decrease insulin resistance leading to lower blood sugar levels. These factors may help limit weight gain and accumulation of fat storage and prevent or improve metabolic syndrome.9

Bacteria

Honey and Green/Black Tea
May Have Antibacterial Properties

One study found honey and green/black tea reduced the risk of H. pylori infection. This study may lead to further studies evaluating the use of honey and tea in the prevention or treatment of some infections.10

Green tea (camellia sinensis) is one of the world’s most popular and healthy drinks. This tea, along with oolong and black tea, has been consumed in China and India for fifty centuries. 

The antioxidant substances in tea leaves may help with several health-related problems, including hypertension, hyperlipidemia, weight loss, neurological disorders, and more. 

In addition, if you use raw honey to sweeten your green tea, more antioxidants will be available to help reduce cellular oxidation.

I highly recommend adding green tea and honey to your diet. Your body will thank you.

If you have any questions regarding this or any other post, please email me at [email protected]. I try to answer all emails.

Michael Brown in Lab Coat with arms crossed

Michael J. Brown, RPh, BCPS, BCPP

Mr. Brown is a Clinical Pharmacist specializing in pharmacotherapy and psychiatry.

Read Michael’s story here.

Feel free to send Michael a message using this link.

 
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Psilocybin for Depression and Anxiety

Posted on by Michael Brown

Can the psychoactive substance found in “magic mushrooms” be used to treat depression?

Psilocybin is a hallucinogenic drug present in some species of mushrooms. This compound was utilized in the 1960’s for various psychiatric conditions before being classified as a schedule I substance by the FDA in 1970. 

Schedule I substances have no current acceptable medical use and have a high potential for abuse. 

Some examples of Schedule I substances are heroin, LSD, and PCP.

Recently, some cities have decriminalized psilocybin. The first to do so was Denver, Colorado, in May of 2019.  

The first state to legalize psilocybin is Oregon, where I live. Measure 109 passed in November of 2020. This measure allows the Oregon Health Authority (OHA) to develop a program to enable licensed providers to administer mushrooms and fungi containing psilocybin to individuals over 21.

This measure opens the door for psilocybin to be used for psychiatric conditions where traditional treatment has failed.

What is Psilocybin?

Psilocybin is a psychedelic substance that alters consciousness through interaction with serotonin (5HT2A) receptors.

The question is whether this substance has any benefit for these conditions. To answer this question, I looked at the available studies.

 

Psilocybin Treatment for Anxiety and Depression in Cancer Patients

Cancer patients commonly suffer from significant anxiety and depression. It is estimated that 30-40% of these patients are affected by these disorders when hospitalized.

Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: a meta-analysis of 94 interview-based studies.1

Anxiety and depression are associated with a variety of symptoms that lead to poor outcomes.  Some of these include:

2

3

 

4

  • Increased suicide rates.
  • Increased disability
  • Poor medication compliance.
  • Increased health care utilization.
  • Decreased quality of life.
  • Increased pain.
  • Decreased social functioning.
  • Decreased survival rates.

Although this is a significant problem, no FDA-approved pharmacotherapies are approved for psychological distress related to cancer. Antidepressant agents take time to take effect, side effects compromise treatment adherence, many treatments are ineffective, and relapse rates are significant.5

 

6

A double-blind, placebo-controlled, crossover trial involving 29 patients with cancer-related anxiety and depression was published in the Journal of Psychopharmacology in December of 2016.7

This study was designed to determine the efficacy of a single psilocybin dosing session compared to an active control (niacin 250mg) in treating cancer patients with anxiety and depression.  

The investigators concluded that moderate-dose psilocybin (along with psychotherapy) produced rapid and sustained anxiolytic and anti-depressant effects.  These effects lasted anywhere from 7 weeks to 8 months. These patients exhibited decreased cancer-related existential distress, increased spiritual well-being, quality of life, and improved attitudes towards death.

There were no serious adverse effects reported during this study in either group.

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Psilocybin in Unipolar Depression

An open-label study of 12 patients with moderate-to-severe, unipolar depression was published in Lancer Psychiatry in July of 2016. This was a feasibility trial involving six men and six women.8

These patients received two oral doses of psilocybin (10mg and 25mg) seven days apart. The figure below represents the Schedule of study interventions for this trial.

This study’s main objective was to create an optimized protocol for psilocybin administration and gain information about its efficacy in treating unipolar depression.

No severe adverse effects occurred during this study, and the psilocybin was well-tolerated. The side effects that did appear were:

  • Anxiety (mostly mild)
  • Confusion or thought disorder
  • Nausea
  • Headache

No prolonged psychosis was observed in any of the subjects.

Depression severity was measured using the Quick Inventory of Depressive Symptomatology (QIDS) score. Scoring is as follows:

>21 – Very severe depression

16-20 – Severe depression

11-15 – Moderate depression

6-10 – mild depression

5 or below – No depression

<=9 – Indicates remission of depression

 

All scoring was completed at the intervals shown on the graph below. The time period reflects time passed after the high-dose session. The figure below shows the results over time. These results were also confirmed using the Beck’s Depression Inventory Scale.

Every patient had a reduction in depression severity one week after the high-dose session. Week 2 showed the most significant results. Eight of the twelve patients (67%) achieved complete remission at week one, and five of these (42%) were still in remission at three months.

Although this was a study with a small sample size and no control group, it is promising that many of these treatment-resistant patients achieved remission of their depression. More studies are needed to confirm what was gleaned from this study, but it appears that psilocybin can be safely administered to patients who are appropriately screened and receive adequate support.

Anxiety and depression are prevalent in today’s society. Many of our traditional antidepressant medications take weeks to work and are often ineffective. Psilocybin shows promise in the management of those with treatment-resistant anxiety and depression.

Psilocybin is also associated with only minor side effects. It does not typically cause compulsive drug-seeking behaviors and is relatively non-toxic.  

In addition to the studies mentioned above, psilocybin has also had positive effects on smoking cessation.9

It has also been shown to significantly decrease alcohol consumption in alcoholic patients.10

More studies need to be conducted to determine the optimal dose and frequency of psilocybin administration in treating psychiatric disorders. One thing is certain; we desperately need more treatments for anxiety and depression.  

If you have any comments regarding this post or any other, please feel free to contact me through the link in the author box below.

As always, have a happy week and stay safe!

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Michael J. Brown, RPh, BCPS, BCPP

Mr. Brown is a Clinical Pharmacist specializing in pharmacotherapy and psychiatry.

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Several Shitake Mushroom Benefits

Posted on by Michael Brown

What are the health benefits of shitake mushrooms?

Should you try to eat more?

What if I don’t like to eat mushrooms?

 

Shitake mushrooms (Lentinula edodes) are native to East Asia and are the second most popular mushroom consumed today. Shitakes have been a staple in Asian cuisine for centuries. These mushrooms have a meaty texture and are an excellent addition to salads and soups. 

They also provide a great meat substitute.

Shitakes are tan to dark brown and typically grow on decaying hardwood trees in warm, moist climates. Japan produces about 83% of the shitake mushrooms available worldwide, and 60% of all shitakes are dried before consumption.1

These mushrooms not only provide many vitamins but also are thought to possess other medicinal properties. This post will explore some of the many benefits of this delicious mushroom.

Shitake Mushroom Nutritional Facts

Before exploring the medicinal benefits of the shitake mushroom, lets take a look at the nutritional value of this mushroom.2

The information below represents the nutritional value of one cup (145 g) of shitake mushrooms:

  • Calories 81.2 kcal
  • Protein 2.26 g
  • Fat 0.319 g
  • Carbohydrate 20.9 g
  • Fiber 3.04 g
  • Sugars 5.57 g

These mushrooms also contain many vitamins and minerals.

Medicinal Qualities of Shitake Mushrooms

Natural products, or nutraceuticals, are very important in developing and discovering new pharmaceuticals used in the treatment of chronic diseases such as cancer.3

Polysaccharides present in mushrooms are thought to have antitumor and immune system activation properties.4

Shitake mushrooms contain polysaccharides, lipids, sterols, and terpenoids, which may effectively treat various tumors and infections.5

Antioxidant Effects of Shitake Mushrooms

As we age, our bodies are less efficient at preventing the damage caused by oxidative stress.6

Nutraceuticals, such as shitake mushrooms, can be used to help reduce the oxidation caused by free radical species.7

One study published in 2013 found aqueous extracts of L. edodes demonstrated catalase-like activity leading to the conclusion that shitake mushroom extracts may be a potential source of antioxidants.8

This is important because oxidative stress is known to contribute to over 200 diseases.

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Antiviral and Antibacterial Activity of Shitake Mushrooms

With all that is happening in the world today regarding COVID-19, it isn’t surprising to learn that many people are searching for antiviral nutraceuticals. Shitake mushroom extract has been shown to inhibit viral replication in poliovirus and bovine herpesvirus in a concentration-dependent manner.9

These mushrooms have antiviral, antifungal, and antibacterial properties.10

11

Mushrooms contain Beta-glucans, which are polysaccharides that stimulate the immune system. This leads to the ability to help fight bacteria, viruses, parasites, and fungus. These molecules are necessary for the mushroom’s survival.

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Shitake Mushrooms Contain Vitamin D

Did you know that mushrooms are the only natural plants that contain vitamin D?

It is well-known that this vitamin is crucial for healthy bones and teeth.

The concentration of vitamin D found in mushrooms is dependent on their exposure to Ultraviolet light and how they are grown.

A study performed on mice found that those fed UV-enhanced shitake mushrooms had a higher bone density than a group provided a low-calcium, low-vitamin-D diet.12

Shitake Mushrooms May Help Fight Some Types of Cancer

A cohort study of 36,499 Japanese men found an inverse relationship between mushroom consumption and prostate cancer incidence.13

One polysaccharide, lentinan, assists in fighting tumors as a result of immune system activation.14

 

15

Shitake mushroom extract has also been shown to decrease the proliferation of leukemia cells significantly.16

Mycologists strongly believe that the compounds found in mushrooms can suppress many forms of cancers at several stages.

Many plant and fungal species have been used as food and medicine in traditional Chinese medicine for centuries. These products have shown the ability to promote good health and may even prevent or treat many diseases.


Mushrooms are loaded with vitamins, minerals, and other compounds that can positively affect our bodies. Mushroom supplements have recently gained popularity in the United States for people who desire mushrooms’ health benefits but do not enjoy them as a food source. These supplements also allow one to consume mushrooms in a concentrated form.

As with most nutraceuticals, more clinical studies are needed to determine the many uses for mushrooms, such as shitakes.
The benefits of consuming these appear to outweigh any risks.

As always, if you have any questions regarding this post or any other, please send me an email. I attempt to answer all emails I receive.

Have a great week, and stay safe out there.

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Michael J. Brown, RPh, BCPS, BCPP

Mr. Brown is a Clinical Pharmacist specializing in pharmacotherapy and psychiatry.

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Feel free to send Michael a message using this link.

 

 
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Krill Oil vs Fish Oil: What is the Difference?

Posted on by Michael Brown

Are krill oil and fish oil the same?

Which one should you take?

What are the benefits of these supplements?

I receive a lot of questions regarding the differences between krill oil and fish oil.  I decided to answer this question and explore the benefits of these supplements.  Let’s start with the basics.

The traditional fish oil supplements are derived from fatty fish such as salmon, anchovies, tuna, herring, sardines, and mackerel.  Fish oil is one of the most popular dietary supplements consumed world-wide.

Krill oil comes from Antarctic krill, which are tiny crustaceans.  Krill is consumed by other sea animals such as penguins, whales, seals, and birds.

Krill Oil and Fish Oil Both Contain Omega-3 Fatty Acids

Omega-3 fatty acids are necessary for proper brain and nerve function.  They are an essential component of the membrane that surrounds each of our cells.  Omega-3’s are known as essential fatty acids because they must be obtained from food sources as our bodies cannot produce them.1

 Krill oil and fish oil both contain eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).  These are omega-3 fatty acids that have the ability to improve brain health and heart health.   The difference is how fatty acids are stored.  It appears that krill oil stores omega-3’s as phospholipids, whereas fish oil stores them as fatty acids.

This may be an important factor in how our body utilizes them.  There have been some small studies comparing Fish oil and krill oil.  One study published in 2015 found a higher plasma concentration of EPA and DHA in subjects receiving krill oil compared to those who ingested fish oil supplements.2

Omega-3 supplements have the following benefits:

  • Decreasing high triglyceride levels – When your triglyceride levels are too high, the risk of atherosclerosis and heart disease increases.
  • Treatment of rheumatoid arthritis – Some evidence suggests Omega-3 fatty acids may help with the treatment of rheumatoid arthritis. One study published in 2017 concluded that “higher intake of vitamin D and omega-3 fatty acids during the year preceding disease-modifying antirheumatic drugs may be associated with better treatment results in patients with early rheumatoid arthritis.”3

Krill Oil Contains Astaxanthin

Astaxanthin is a carotenoid pigment that has many health benefits of its own. This substance gives krill oil its reddish color and is not found in most fish oil supplements.

Astaxanthin acts as an antioxidant and anti-inflammatory and may promote cardiac health.4

Krill Oil May Be More Effective in Treating Hyperlipidemia

A multi-center randomized, controlled study found krill oil to be significantly more effective than fish oil in reducing glucose, triglyceride, and LDL levels.5 

Krill oil was also able to significantly lower total cholesterol and increase HDL levels in this study.  

Other Sources of Omega-3s

Omega-3 fatty acids naturally occur in some foods and are artificially added to others.  Some examples include:6

  • Fish and seafood (especially salmon, herring, sardines, mackerel, and tuna).
  • Plant oils (flaxseed, soybean, and canola).
  • Nuts and seeds (Chia seeds, walnuts, flaxseed).
  • Fortified foods (some eggs, yogurt, milk, juice, and soy beverages).

Other sources include cod liver oil and algal oil.  Algal oil is derived from algae and is a great choice for vegans and vegetarians.

Is Fish Oil Easier to Obtain?

Fish oil supplements can be found in most grocery stores.  Krill oil is becoming more popular, and with the ability to order supplements over the internet, it is certainly not difficult to obtain.  Fish oil may be cheaper than krill oil. Our omega-3 product is reasonably priced and is high quality.

Side Effects of Krill Oil and Fish Oil

The side effects of krill oil and fish oil are similar and very mild.  These include:

  • Diarrhea
  • Headache
  • Upset stomach and heartburn
  • Bad breath
  • Fishy smelling sweat
  • Acne and oily skin
  • Nausea
  • Flatulence
  • Fishy burps

Drug Interactions

Both fish oil supplements and krill oil can interact with the following drugs:7

  • Anticoagulants and Antiplatelet drugs – Bleeding risk may increase.
  • Antidiabetic drugs – Hypoglycemia risk may increase.
  • Orlistat – May decrease the absorption of krill oil or fish oil.

Should You Take Krill Oil or Fish Oil?

Although the evidence isn’t substantial, I prefer krill oil.  My reason for this is that it may be more bioavailable and has the additional benefit of containing an antioxidant.  Krill oil is not hard to find, and it doesn’t cost that much more to obtain.  Krill oil also doesn’t have the fish odor associated with fish oil supplements. 

It is crucial to ingest essential fatty acids for the proper functioning of the body.  These molecules are important for our cell membranes and  proper brain and nerve function.  Always remember that getting these fatty acids from your diet is a better choice than taking supplements.  The healthiest way to live is to eat a well-balanced diet utilizing mostly whole foods, drink plenty of water, exercise regularly, and get an adequate amount of sleep.

If you don’t believe you are getting enough essential fatty acids, then take a supplement.  I prefer krill oil for the reasons stated above, but fish oil is also a good choice.  Be sure to talk to your physician or pharmacist if you are allergic to shellfish before taking krill oil.  If you use blood-thinning medications, always check with your physician or pharmacist prior to taking any supplement. 

I am always happy to answer questions regarding drugs or supplements.  Send me an email, and don’t forget to sign up for our monthly newsletter below.  You will receive company news and coupon codes for savings on all of our products.

Have a great week, and be happy and healthy.

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Michael J. Brown, RPh, BCPS, BCPP

Mr. Brown is a Clinical Pharmacist specializing in pharmacotherapy and psychiatry.

Read Michael’s story here.

Feel free to send Michael a message using this link.

 

 
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Some Great Bacopa Benefits

Posted on by Michael Brown

What are the benefits of this herb?

Are there side effects?

What can Bacopa do for you?

Bacopa monnieri is a plant that grows in tropical, moist environments in India, Africa, Australia, Europe, and North and South America. This herb has been used for thousands of years in Ayurvedic medicine that originated in India and is one of the oldest medical systems in the world. 

Bacopa is best known for its use as a neural tonic and memory enhancer.  It has been used for centuries by the Hindus in rituals involving new-born babies in the belief that it will open gateways to knowledge.  This herb is also thought to have been used by ancient Vedic scholars to memorize extensive hymns and scriptures.

Besides its use as a nootropic, Bacopa has shown promise in attenuating dementia, Parkinson’s disease, and epilepsy.1

Cognitive Enhancement With Bacopa

Enhancing cognitive function often comes with unwanted side effects.  These can be psychological or the result of toxicity.2

 

3

 

4

 

5

Bacopa contains saponins, which are nootropic phytochemicals that produce only minimal adverse effects when consumed in standard dosages.  These chemicals:

  • Possess Antioxidant activity.6
  • May protect the liver.7
  • Possess neuroprotective activity.8

 

I have a particular interest in cognition because I work on a senior psychiatric unit where a large number of patients have some form of dementia. 

Bacopa helps repair damaged neurons, restores synaptic activity, assists with neuronal synthesis, and improves brain function. 

The primary molecular mechanism is achieved by promoting neuronal communication.  This is accomplished by increasing the growth of nerve endings called dendrites.9

 

10

 

11

Bacopa has been shown to improve delayed recall memory and Stroop task reaction times.12

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Antioxidant Effects of Bacopa

The detrimental effects of free radical cell damage are well known.  This damage is linked to many diseases, including diabetes, heart disease, and certain types of cancer.13

The human body has both enzymatic and non-enzymatic free radical scavenger mechanisms to help cells fight oxidative stress. 

Superoxide dismutase (SOD), catalase (CAT), and glutathione reductase are the first line of defense.  The non-enzyme scavengers are vitamin A,C, and E, coenzyme Q10, glutathione, and selenium. 

When an imbalance occurs, as shown in the figure below, free radical damage can lead to aging and cognitive decline.14

Figure 1.15

Bacopa contains powerful antioxidants.16

An extract of Bacopa monnieri was shown to increase the activity of SOD, CAT, and glutathione peroxidase in the prefrontal cortex, hippocampus, and striatum of rats.17

This antioxidant effect has been shown to reverse memory impairment produced in rats using colchicine by attenuating oxidative damage.  This study suggests there may be potential in using Bacopa in the treatment of Alzheimer’s dementia in the future.18

Bacopa and ADHD

A study published in 2014 found a standardized Bacopa monnieri extract significantly reduced all ADHD symptom scores except those relating to social problems.19

Here are the results obtained from this study:

  • Symptom scores for restlessness decreased in 93% of children.
  • Improvement in self-control occurred in 89% of children.
  • ADHD symptoms were reduced in 85% of children.
  • Learning problems were reduced in 78% of children.
  • Impulsivity was reduced in 67% of children.
  • Psychiatric problems were reduced in 52% of children.

The study concluded that B. monnierei was effective in relieving the symptoms of ADHD and was well tolerated.

Other Medical Uses of Bacopa

There are many other possible medical uses of Bacopa.  Some of these include:

  • Anxiety
  • Epilepsy
  • Depression
  • Anti-inflammatory
  • Analgesic
  • Anti-microbial
  • H-Pylori and ulcers
  • Stimulation of the immune system
  • Adaptogenic
  • Anti-neoplastic

More studies need to be conducted in order to discover the many benefits of this herb.

Side Effects of Bacopa

Adverse effects reported in clinical trials include:20

  • Increased stool frequency (30%)
  • Nausea (18%)
  • Abdominal cramps (16%)

Less common effects include:21

22

  • Bloating
  • Decreased appetite
  • Dry mouth
  • Fatigue
  • Flatulence
  • Headache
  • Insomnia
  • Palpitations
  • Vivid dreams

Protandim NRF2 Synergizer

Bacopa monnieri is a fantastic substance capable of many positive medicinal effects.  As with other nootropics, when stacked with other nootropic agents, synergy is possible.  The right herbs combined in the correct ratios can lead to excellent results. 

LifeVantage has developed the ProtandimTM series to improve the health of its customers around the world.  I am proud to be involved with this company.  I believe these products are the best available today, and I take them daily.

Bacopa monnieri has been used in ancient medicine for thousands of years. 

It is a popular addition to nootropic stacks and is one of the five ingredients present in ProtandimTM  NRF-2 Synergizer. 

I take all three ProtandimTM Products daily, along with AXIOTM Energy.  I was so impressed with these products that I signed up as a distributor.  I wanted to be able to offer these cutting-edge products to my Sunshine Nutraceutical’s customers.

It is critical to realize that these herbal supplements can be much more effective when combined with other substances in the proper ratios.  The ProtandimTM series is able to activate the body’s natural pathways in order to achieve superior results.

Click on the banner below to read more about these innovative products.

Finally, if you are the entrepreneurial type and want to build a lucrative business for you and your family, send me an email.  I can help you get started. 

This is one of the most positive life decisions I have made.  A chance to build a business where you learn personal growth skills while helping others become healthy is fulfilling.

If you have any questions about this post or any medication or natural supplement, please feel free to reach out.  I attempt to answer every email I receive. 

Have a great week! 

Be happy and healthy, and stay safe!

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Michael J. Brown, RPh, BCPS, BCPP

Mr. Brown is a Clinical Pharmacist specializing in pharmacotherapy and psychiatry.

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Kratom Euphoria and Other Properties

Posted on by Michael Brown

Kratom is derived from an evergreen tree in the coffee family that is native to Southeast Asia. 

This tree’s leaves are often chewed and used as a stimulant for workers in the tree’s native country. 

They may also be brewed into a tea and used as a sedative and analgesic.1

 

The different effects of Kratom depend on the dose ingested. The low doses obtained from chewing on the leaves cause stimulation, including increased alertness, talkativeness, and physical energy. At higher doses, obtained from drinking Kratom tea, sedation occurs.2

 

Although Kratom is prohibited in Malaysia due to the Poisons Act of 1952, it is still widely used because it grows natively, and teas are readily available locally.3

Kratom Survey 2016

Kratom has gained popularity in the United States in recent years. An anonymous online survey conducted in October of 2016 attempted to answer several questions regarding its use. The survey was sent to 10,000 current Kratom users, and 8049 replied. Here are some of the findings.4

Most Kratom users are 31-50 years old.

They use Kratom for the following reasons:

  • Treatment of pain (68%)
  • Emotional or mental conditions (66%)
  • Treatment of withdrawal symptoms associated with prescription opiate use.

Most side effects involve nausea or constipation.

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Mechanism of Action

The active chemicals present in Kratom are mitragynine and 7-hydroxymitragynine. These alkaloids are thought to work on opioid receptors as partial agonists.5

 

These actions are too complex to discuss here, but it appears that these compounds can provide opiate effects with less respiratory depression.6

 

Opiates are the main medications used to treat severe pain. Opiates also cause many adverse effects, such as respiratory depression, constipation, drowsiness, and dizziness.

 

The alkaloids found in Kratom may prove to be very beneficial as pain medications because respiratory depression is dangerous, and can cause death in opiate overdose.

Kratom Euphoria

The primary purpose of this post is to describe the euphoric effects of Kratom. Knowing that the alkaloids in this plant interact with opiate receptors, it is not surprising that euphoria can occur. The effects of Kratom can vary between individuals, but some of the euphoric effects I could locate include.

 

 The kratom user’s guide. Sage Wisdom Web site. http://www.sagewisdom.org/kratomguide.html. Accessed August 27, 2020.

  • A general feeling of comfortable pleasure.
  • Less sensitive to physical and emotional pain.
  • May experience pleasant daydreams.
  • Increased appreciation of music.

It should be noted that the above experiences were described by those who had Kratom products for sale. I have no personal experience with this substance, so I am unable to confirm such effects.

Side Effects of Kratom

Kratom can cause several adverse effects. When used in doses up to 5 grams, Kratom may cause:7

  • Nausea and Vomiting
  • Loss of appetite
  • Poor muscle coordination
  • Increased urination
  • Dizziness

At higher doses, 8 grams or more, one may experience:8

  • Rapid heart rate
  • Constipation
  • Sedation
  • Fluctuations in blood pressure
  • Sweating
  • Dry mouth

There have also been case reports of other serious side effects of Kratom. One of the most concerning is liver damage. One case report involved a 25-year-old man who ingested between one to six teaspoons of Kratom powder daily for two weeks. This patient developed intense abdominal pain, brown urine, itching, and profound jaundice.9

There have been reports of withdrawal symptoms occurring after the habitual use of Kratom.10

Kratom has also been implicated in at least 91 drug-related deaths.11

 

12

 

13

It is important to note that multiple drug exposures were present in most of these cases.

Kratom Drug Interactions

CNS Depressants – Combining Kratom with other CNS depressants may lead to fatal respiratory depression. Fatalities have been reported in patients who have ingested Kratom along with the mu-receptor agonist O-desmethyltramadol.14

 

Drugs that are metabolized by cytochrome P450 enzymes – Many medications are metabolized in the liver through the cytochrome P450 enzyme system. Kratom has been shown to inhibit this process.15

 

  The combination of Kratom with C-450 substrates may increase blood levels and lead to toxic effects. There are too many affected medications to list here, but they can be found at the TRC natural medicines databaseTM.

16

 

Modafanil (ProvigilTM) – When Kratom is ingested along with modafinil, the risk of seizures may increase.17

 

Quetiapine (SeroquelTM) – The combination of Kratom and quetiapine may lead to increased quetiapine plasma levels. This is also due to C-P450 enzyme inhibition. A 27-year-old male was found deceased due to this combination.18

 

Kratom has been used in Southeast Asia for hundreds of years.19

 

20

 

It has gained popularity here in the USA and is widely available in smoke shops and through the internet.  

 

I believe that Kratom’s alkaloids may lead to alternative medications to treat pain in the future. The fact that these substances can treat pain and cause less respiratory depression is promising.  

 

After researching Kratom, I cannot recommend its use. 

Although it may be beneficial for those suffering from opiate withdrawal, the adverse effects can be severe. 

 

It also seems to be another substance used to “get high.” Using substances to achieve a euphoric effect is never a good idea.  

 

Another issue with Kratom is that it is often mixed with other mind-altering substances or medications. This can lead to toxic blood levels. There are several case reports involving Kratom, causing death and liver damage when combined with other substances.

 

If you have any questions regarding Kratom or any other medication or natural product, please contact me. I hope you all have a great week and please stay safe out there!

 

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Michael Brown in Lab Coat with arms crossed

Michael J. Brown, RPh, BCPS, BCPP

Mr. Brown is a Clinical Pharmacist specializing in pharmacotherapy and psychiatry.

Read Michael’s story here.

Feel free to send Michael a message using this link.

 

 
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Some Remarkable Over The Counter Antivirals

Posted on by Michael Brown

The threat of COVID-19 has prompted a lot of questions regarding over the counter antiviral remedies. I thought I would discuss a few herbs that are thought to possess activity against viruses in general. We do not have specific information regarding COVID-19 because it is too new.  

Presently, the only known weapons we have against the spread of COVID-19 are handwashing, social distancing, and wearing masks. 

Until a vaccine is available, our options are limited. I take dietary supplements for several reasons. Some of these may help decrease my risk of contracting this virus. 

I believe benefit far outweighs the risk in this situation.

I have written about many of these herbs in the past. For more information, click the highlighted link to visit the corresponding blog post.

Green Tea

Green tea (Camelia sinensis) consumption can have significant positive effects on human health.1

Green tea contains catechins, which are polyphenolic compounds. These substances, especially epigallocatechin-3-gallate (EGCG), have shown broad antiviral effects.2

Green tea extract has the potential to cause liver toxicity. Products that contain the United States Pharmacopeia (USP) verification stamp must be labeled with the following:

Due to the potential risk for hepatotoxicity with green tea extracts, products that carry the United States Pharmacopeia (USP) verification stamp must include the following text on the label: “Do not take on an empty stomach. Take with food. Do not use if you have a liver problem and discontinue use and consult a healthcare practitioner if you develop symptoms of liver trouble, such as abdominal pain, dark urine, or jaundice (yellowing of the skin or eyes)”3

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Ascorbic Acid ( Vitamin C)

Studies have shown that patients with acute infections have low circulating ascorbic acid levels.4

 

5

We also know that vitamin C modulates interferons and cytokines in patients with viral infections.6

Ascorbic acid has also been shown to reduce neuralgia pain associated with the herpes virus.7

There have also been instances where influenza A patients with life-threatening respiratory failure have rapidly improved after receiving ascorbic acid and thiamine.8

Elderberry

Elderberry is a dark purple berry that grows on the European elder tree. There is evidence that elderberry fruit extract taken four times daily can reduce the symptoms and duration of influenza infection if started within 48 hours of symptoms. This extract can reduce the duration of symptoms by 56% on average.9

Another study found that lozenges containing elderberries taken four times daily within 24 hours of influenza onset improved flu-like symptoms compared with placebo 10

Zinc

Zinc is the second most abundant trace element in the human body. This element is essential for growth, development, DNA synthesis, and RNA transcription.11

A review article published in 2019 concluded that zinc can stimulate the body’s viral response.12

In vitro studies have also shown zinc may possess antiviral effects. This paper also stated that zinc treatment at therapeutic doses can drastically improve the clearance of acute and chronic viral infections.13

We know that Zinc lozenges can decrease the duration of the common cold by up to 40%.14

Quercetin

Quercetin is a common flavonoid found in many Chinese herbs and fruits, vegetables, and red wine.  

Quercetin has been shown to possess anti-influenza activity. This is likely due to its ability to inhibit the entry of the virus into the cell.15

This substance has also exhibited the ability to inhibit virus replication in the initial stages of influenza infections.16

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Echinacea

Echinacea is the name given to some flowering plants in the daisy family. This plant has been used for centuries by Native Americans to treat many illnesses. 

Currently, Echinacea is used primarily as an herbal remedy in the treatment of the common cold and flu.

 Echinacea extracts have shown antiviral activity against several different viruses.17

 

18

 

19

There are also studies claiming Echinacea is an efficacious immunomodulator. There is still insufficient evidence available to make therapeutic recommendations for specific disease states.20

We all want to protect ourselves from infection. 

It is much easier to prevent an illness than to treat it. There are some simple steps we can take to stay healthy.

  • Eat whole foods.
  • Exercise regularly.
  • Drink plenty of water.
  • Avoid bad habits.
  • Get enough sleep.

I also believe herbal products can help us stay healthy. One of the biggest causes of sickness is oxidative stress. Our cells are bombarded with free radicals daily. 

Just breathing the air can introduce toxins into the body.  

In addition to my products, I take ProtandimTM Tri-Synergizer daily. This not only helps protect my cells from free radical damage but also makes me feel better and improves my energy level. I strongly recommend giving this supplement a try.

With COVID-19 comes uncertainty and fear. Besides staying as healthy as possible, we should also wash our hands often, wear masks when near others, and practice social distancing. Although the products mentioned in this post are not proven to treat, prevent, or cure COVID-19, some have good evidence against other viruses. I think the benefits of taking them far outweigh the risks.

Nutraceuticals have been used in Ayurvedic and Chinese medicine for thousands of years. Large, randomized-controlled studies are not always available to support these agents due to prohibitive costs. This does not mean they are ineffective. It usually means there is not enough profit to be made from them to justify the high costs of the studies.

If you have any questions regarding this post or about medications or nutraceuticals, please send me a message. I would also like to invite you to join our email list to receive our monthly newsletter. Our newsletter will keep you up to date on new products, our influencers, and sales.

Until next week, stay happy, healthy, and safe!

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Michael Brown in Lab Coat with arms crossed

Michael J. Brown, RPh, BCPS, BCPP

Mr. Brown is a Clinical Pharmacist specializing in pharmacotherapy and psychiatry.

Read Michael’s story here.

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