Natural Anxiety Relief: A Pharmacist’s Supplement Picks

By /
Supplements and herbs

Anxiety is a common mental health condition characterized by persistent worry, nervousness, and physical symptoms like a racing heart or tension. While prescription medications (such as benzodiazepines or SSRIs) are effective for many, they can come with side effects (like drowsiness or sexual dysfunction) and potential dependency issues. This has led many people to seek natural remedies for anxiety relief.1

In this post, we’ll explore some of the best evidence-backed natural supplements for anxiety, how they work, typical dosages, and their pros and cons. We’ll also compare these natural options to conventional medications and discuss safety considerations. (Always consult a healthcare professional before starting any supplement, especially if you have underlying health conditions or take other medications.)

 

Ashwagandha is an Ayurvedic herb known for its stress-reducing and anxiolytic effects.


 What it is: Ashwagandha is an evergreen shrub and popular adaptogenic herb in Ayurvedic medicine. Adaptogens help the body resist physical and mental stress. The name somnifera means “sleep-inducing,” hinting at its traditional use for calm and rest.2

Click Here

How it works: Ashwagandha’s active compounds (withanolides) are thought to modulate the stress response by lowering cortisol (a stress hormone) and influencing neurotransmitters like GABA.3 

This can lead to reduced anxiety and improved resilience to stress.

Evidence: Multiple clinical studies support ashwagandha’s anti-anxiety benefits. A 2021 systematic review of 7 randomized trials (491 adults) found that ashwagandha supplementation significantly reduced anxiety levels and stress compared to placebo.4  Participants taking ashwagandha had lower anxiety scores, better sleep, and reduced cortisol. In several trials, doses of 500–600 mg/day of a standardized extract were more effective than lower doses.5  Another clinical trial found ashwagandha improved anxiety, mood, and even food cravings in stressed adults over 30 days.6 

These studies indicate a tangible calming effect for people with chronic stress or anxiety.

Typical dosage: 300–600 mg per day of a standardized ashwagandha root extract (often given in divided doses) is common. Many studies used ~500 mg/day. Some traditional preparations use higher doses of powdered root (e.g. 3–6 grams), but extracts are more concentrated. Starting with 300 mg and adjusting upward is a prudent approach. Benefits are usually observed after a few weeks of daily use, rather than immediately.

Safety: Ashwagandha is generally well-tolerated for up to 2–3 months.7  Mild side effects can include upset stomach, diarrhea, or drowsiness.8

 Important precautions: There have been rare case reports of liver injury with ashwagandha supplements (often in combination with other supplements or medications).9  It may also affect thyroid hormone levels, so use caution if you have thyroid disorders.10  Ashwagandha is not recommended during pregnancy, as high doses might influence hormone levels or uterine activity.11  Always purchase from reputable brands to ensure quality, and consult a doctor if you’re on thyroid medication, immunosuppressants, sedatives, or have autoimmune conditions, as ashwagandha could potentially interact.12

The kava plant, native to Pacific islands, has roots rich in kavalactones that can reduce anxiety.


 What it is: Kava (also called kava kava) is a plant native to Polynesia. Its roots have been used ceremonially for centuries as a relaxing drink. The active constituents, kavalactones, have anxiolytic (anti-anxiety) properties. Kava supplements are typically made from root extracts standardized to kavalactone content.

How it works: Kavalactones in kava interact with the brain’s GABA receptors – the same inhibitory neurotransmitter system targeted by benzodiazepine drugs.13 

By enhancing GABA activity, kava produces a calming, tranquilizing effect without impairing mental clarity in moderate doses. Kava may also influence other brain pathways involved in mood and stress (such as dopamine and norepinephrine) and has mild muscle-relaxant properties. Users often report feeling more relaxed and sociable after taking kava.

Evidence: There is substantial clinical evidence that kava can reduce anxiety. A meta-analysis of 7 clinical trials (380 patients) found kava extract significantly reduced anxiety symptoms compared to placebo on the Hamilton Anxiety Rating Scale.14  Although the average improvement was modest, kava was consistently better than placebo for short-term anxiety treatment. In one trial, a specific kava extract (WS 1490) for 6 weeks was as effective as low-dose buspirone and opipramol (an anxiolytic drug).15  Overall, multiple randomized controlled trials have shown kava provides mild to moderate anxiety reduction in conditions like generalized anxiety disorder (GAD).16   Importantly, side effects in these studies were generally mild and transient, and no signs of dependency or withdrawal were observed with kava.17  

One notable study compared kava to a benzodiazepine: © A six-week trial in GAD patients found that an optimized kava extract (approximately 120–240 mg kavalactones per day) worked as well as 0.5 mg lorazepam (Ativan) daily in reducing anxiety – with the added benefit that kava caused no sedation or mental impairment.18  Both treatments reduced anxiety by about 45% on rating scales, but unlike the drug, kava did not induce drowsiness or dependency.19 

This head-to-head comparison highlights kava’s potential as a natural alternative for mild to moderate GAD.

pretty sunset at a lake

Typical dosage: 60–250 mg of kavalactones per day is the usual range for therapeutic effects.20   Many kava supplements are standardized; for example, one common regimen is 70 mg kavalactones, 3 times daily (210 mg/day). Higher doses (300 mg+) may increase risk of side effects without much added benefit. It’s advised not to exceed 250–300 mg of kavalactones per day to stay within safe limits.21 

Kava is often taken in the evening or split between afternoon and evening to ease anxiety and stress. Avoid alcohol on kava days, as both have sedative effects and can strain the liver.

Safety: Kava requires some caution. Earlier reports raised concerns about liver toxicity. While subsequent analyses found that serious liver damage from kava is rare and idiosyncratic, there have been cases of hepatitis and liver failure in people using kava (especially when combined with other hepatotoxic substances)22  For this reason, kava is banned in some countries. Generally, short-term use of kava (up to 24 weeks) in studies has not shown significant liver issues in healthy individuals.23  To be safe, you should avoid kava if you have liver disease or drink alcohol heavily, and refrain from other liver-stressing drugs while using kava. It’s wise to limit duration (e.g. use for a few weeks to a few months, then break) and monitor for symptoms like yellowing of skin or fatigue. Other side effects can include drowsiness, dizziness, or gastrointestinal upset, but these are usually mild.24  High doses or chronic use of kava has been linked to a reversible skin rash/dry skin (kava dermopathy) in heavy kava drinkers. Because kava can potentiate sedation, do not combine it with other CNS depressants (benzodiazepines, barbiturates, alcohol). Pregnant or breastfeeding women should avoid kava. When used responsibly, research reviews conclude “the benefits of kava appear to outweigh its risks” for short-term anxiety relief25 but one should always use the lowest effective dose and stay vigilant about liver health.

L-Theanine, found in green tea, promotes relaxation without sedation.


 What it is: L-theanine is an amino acid primarily found in green tea leaves (Camellia sinensis). If you’ve ever felt relaxed yet alert after a cup of green tea, L-theanine is a big reason why. It is also available as a standalone supplement. L-theanine easily crosses the blood–brain barrier and has subtle psychoactive properties.

How it works: L-theanine increases alpha brain wave activity associated with a relaxed, attentive mental state (similar to meditation). It modulates neurotransmitters – boosting GABA (inhibitory/calming), dopamine, and serotonin while reducing excitatory glutamate signaling.26  This balances brain chemistry towards calmness without causing drowsiness. L-theanine can also reduce physiological markers of stress; for example, it has been shown to lower cortisol and heart rate in acute stress situations.27 

Essentially, L-theanine gently shifts the brain into “rest-and-relax” mode. Many people report that it helps “take the edge off” anxious feelings and improves focus.

Evidence: A growing body of research indicates that L-theanine supplementation can reduce anxiety and stress – especially in people facing stressful situations. In healthy adults with elevated stress, four weeks of daily L-theanine (200 mg/day) led to significant improvements in stress-related symptoms and better cognitive function compared to placebo.28  The participants reported feeling calmer and more clear-headed, without sedation. Another placebo-controlled study found that a single dose of L-theanine (200 mg) reduced acute anxiety and reduced cortisol in response to a stressful task.29  Moreover, a 2020 systematic review of 11 trials concluded that L-theanine significantly reduces anxiety and improved symptoms in people with anxiety disorders and schizophrenia when added to standard treatment.30  Not every study is positive – for example, one trial in generalized anxiety disorder patients found no significant benefit over placebo,31  highlighting that L-theanine’s effects may be more pronounced in stress-induced anxiety or milder cases.) Overall, several studies show L-theanine produces a measurable calming effect without impairing alertness.32  It’s particularly popular for situational anxiety – e.g. taking it before public speaking, exams, or in the evening to unwind.

Typical dosage: 100–400 mg per day. A common supplemental dose is 200 mg, which can be taken 1–3 times daily (morning and/or afternoon/evening) depending on anxiety levels.33 

Even as low as 50–100 mg (the amount in 2–3 cups of brewed green tea) may have mild effects, but most research uses around 200 mg. For acute anxiety relief, 200 mg on an empty stomach can start working within 30–60 minutes. For ongoing anxiety or stress, taking 100–200 mg daily over several weeks is studied. Doses up to 600–800 mg/day have been used in studies without major issues, but it’s wise to start low. Because L-theanine is non-sedating, it can be used during the day; some also pair it with caffeine to smooth out the jitters. Tip: Look for “Suntheanine” or branded pure L-theanine for quality, as it ensures the active L- isomer.

Safety: L-theanine is considered very safe. It’s naturally present in tea (which billions of people consume). Supplements have an excellent safety record: doses up to 900 mg daily for 8 weeks have been used without serious adverse effects.34 

 It typically does not cause drowsiness (in fact, many find it enhances alert relaxation). Side effects, if any, are mild – some people report headaches, or rarely nausea, at higher doses. No dependency or withdrawal concerns. That said, use common sense: extremely high doses might cause hypotension (lower blood pressure) or dizziness in some. And while L-theanine doesn’t usually make you sleepy on its own, it could amplify the effects of sedatives or alcohol, so use caution combining it with other calming substances. Because of its excellent safety profile, L-theanine is a popular first-line “natural anxiolytic” for those who want to stay sharp and calm.

Valerian is a flowering herb whose roots are used to ease anxiety and insomnia.


 What it is: Valerian is a perennial herb native to Europe and Asia, often used as a sleep aid and mild anxiolytic. Supplements are typically made from the root (dried and extracted). Valerian root has a distinct pungent odor (some say it smells like “old socks” or earthy musk), which comes from its essential oils. It has been used since ancient Greek and Roman times for its sedative and calming properties.

How it works: Valerian’s exact mechanism isn’t fully nailed down, but it’s believed to increase the amount of GABA available in the brain by inhibiting the enzyme that breaks down GABA.35  More GABA means more calmness, as GABA is the primary inhibitory (relaxing) neurotransmitter. Compounds in valerian (like valerenic acid) may also directly bind to GABA_A receptors, similarly to how benzodiazepines work, but with a weaker effect.36   Additionally, valerian may influence serotonin and adenosine receptors involved in sleep regulation. Its overall effect is to take the edge off anxiety and promote relaxation, which is why it’s often taken in the evening for both anxiety relief and improved sleep quality.

Evidence: The scientific evidence for valerian in anxiety is mixed. Some studies and user reports find it reduces anxiety and tension, while other studies find no significant benefit. A few open-label or smaller trials suggested valerian can lower anxiety in stress-inducing situations (for example, one study noted reduced anxious behavior in an experimental setup).37  However, a major systematic review (Cochrane, 2006) identified only one rigorous clinical trial on valerian for anxiety disorders – and in that trial, valerian was no better than placebo or than low-dose diazepam for reducing anxiety symptoms.38  In other words, the best available evidence did not show a statistically significant anxiolytic effect in clinically diagnosed anxiety. Because of limited data, researchers concluded there is “insufficient evidence” to confirm valerian’s efficacy for anxiety disorders.39  On the other hand, valerian has a bit more evidence in insomnia – a meta-analysis found it might improve sleep quality without morning grogginess,40which can indirectly help if anxiety is worsened by poor sleep.

In practice, some individuals do report that valerian root (100–300 mg) taken in the evening helps them feel calmer and less restless. It may especially help with sleep-onset anxiety (those racing thoughts at bedtime). For generalized anxiety during the day, valerian on its own may be too mild for noticeable relief (or the sedation could interfere with daytime activities). Thus, while valerian is commonly included in calming herbal blends and has a long history of use, it is probably more effective for mild anxiety or situational tension, rather than as a standalone treatment for severe anxiety. It’s sometimes combined with other calming herbs like passionflower or lemon balm for a synergistic effect.

Check Out Pharmacist Michael on YouTube

Get health and wellness information, podcasts and healthy recipe ideas.
Click Here

Typical dosage: 300–600 mg of valerian root extract taken about 30 minutes to 2 hours before bedtime is a typical regimen for anxiety and insomnia. Some people take lower doses (100–200 mg) during the day for anxiety, but be cautious as it can cause drowsiness in some. The root can also be taken as a tea or tincture, though the strong taste is off-putting to many. In studies, doses have varied; one common preparation is  ~150–300 mg extract (standardized to contain 0.8% valerenic acids) per dose. Because individual responses differ, start on the lower end (e.g. 150 mg at night) and see how you feel. Note: Valerian may take a couple of weeks of nightly use to reach full effect for sleep; for acute anxiety, its benefits (if any) would occur within an hour of taking it.

Safety: Valerian is generally regarded as safe for short-term use, with mild side effects. Because it acts as a sedative, the main side effect is drowsiness or sluggishness – which is why it’s best used when you’re home for the evening. A small number of people paradoxically feel stimulated or anxious after taking valerian (opposite of the intended effect)41if that happens, discontinue it. Other possible effects include headache or dizziness in some users.42  Unlike prescription sedatives, valerian has not shown habit-forming potential and withdrawal symptoms are rare; however, there have been a few reports of withdrawal after very long-term use.43  As a precaution, it’s recommended not to take valerian continuously for more than a few weeks to a few months without a break, unless advised by a doctor, since long-term safety data is limited.44 

If you do use it long-term, taper off rather than stopping abruptly to avoid any possible rebound insomnia.

Interactions: Valerian can enhance the effects of other CNS depressants. That means do not combine it with alcohol, benzodiazepines, opioids, or antihistamine sleep aids – doing so could cause excess sedation or impairment.45  It’s also metabolized by liver enzymes, so it might affect the breakdown of other drugs (like statins or antifungals).46  Always let your doctor know if you’re taking valerian, especially before any surgery (as it can increase sedation with anesthesia.47 

Avoid valerian in pregnancy due to unknown effects, and in children. Overall, valerian is a relatively safe herbal option to promote calm and sleep – just use it responsibly at times when drowsiness is a welcome effect, and keep your healthcare provider in the loop.

Chamomile flowers (German chamomile) are used in teas and extracts to ease anxiety and improve sleep.


 What it is: Chamomile is a well-known herb often consumed as a soothing herbal tea. The two common types are German chamomile (Matricaria recutita) and Roman chamomile; German chamomile is used more in research. The dried flower heads of chamomile contain compounds like apigenin that have mild sedative and anxiolytic properties. Chamomile has been used as a gentle relaxant for centuries – think of having a warm cup of chamomile tea before bed to unwind.

How it works: Chamomile’s relaxation effects are largely attributed to apigenin, an antioxidant flavonoid that binds to benzodiazepine receptors in the brain.48 

By attaching to these receptors, apigenin can produce an anxiolytic effect similar to (but much weaker than) drugs like Valium. Chamomile also has anti-inflammatory effects and may modulate neurotransmitters associated with mood. Its overall pharmacological profile is one of mild tranquilization without strong sedation. In addition, the ritual of drinking a fragrant cup of chamomile tea can have its own calming psychological effect.

Evidence: Although chamomile is mild, there is indeed clinical evidence that it can reduce anxiety in a meaningful way. In a randomized, double-blind trial at the University of Pennsylvania, 57 patients with generalized anxiety disorder (GAD) received chamomile extract (220 mg standardized to 1.2% apigenin, 1–4 capsules daily) or placebo for 8 weeks.49  . Chamomile treatment led to a significantly greater reduction in anxiety scores than placebo (p = 0.047)50  About 57% of the chamomile group had a 50% or greater reduction in anxiety (versus 38% on placebo). The researchers concluded chamomile has “modest anxiolytic activity in patients with mild to moderate GAD.”51 While the effect size was moderate, it’s impressive for an herb – and chamomile was very well tolerated with no serious side effects.52  A follow-up study showed that long-term chamomile therapy (up to 12 weeks) maintained reduced anxiety symptoms in GAD patients and was safe, though it didn’t significantly prevent relapse once chamomile was stopped.53  Beyond GAD, chamomile may help situational anxiety and sleep. Many people find that chamomile tea in the evening reduces daily stress and improves sleep quality. A small study in 2016 found chamomile extract significantly improved sleep quality in people with chronic insomnia (which can be related to anxiety).54 

 Chamomile’s gentle nature makes it a good option for anxiety in children or the elderly who might be sensitive to stronger sedatives – though formal studies in those populations are limited.

In summary, chamomile has peer-reviewed evidence for reducing mild to moderate anxiety, and it stands out as a very safe remedy. It may not eliminate severe anxiety on its own, but it can be a valuable part of a calming routine or a complement to other therapies.

Typical dosage: The most traditional way to use chamomile is as a tea: 1–2 teaspoons of dried flowers steeped in hot water for 5–10 minutes. Many people enjoy 2–4 cups per day (for example, one mid-day and one before bed). For more potent dosing, standardized chamomile extracts in capsules were used in the GAD study – typically 220–1100 mg of extract daily (in divided doses). A common supplement dose is 300–400 mg extract, 1–2 times daily. If using liquid extract, 1–4 mL of tincture in water up to three times a day is a guide. Chamomile is quite forgiving in terms of dosing; start with one cup of tea or one capsule and increase if needed. Note: If you have a ragweed allergy, start with a small dose to ensure you don’t react (chamomile is in the ragweed family).

Safety: Chamomile is one of the safest herbs available. Millions drink it regularly with no issues. The most important caution is that chamomile can cause allergic reactions in people who are allergic to ragweed, chrysanthemums, marigolds, or daisies (they’re all in the Asteraceae family).55  If you have seasonal ragweed allergies, use chamomile carefully – try a small amount first. Another consideration: Chamomile can act as a mild blood thinner. It contains natural coumarins, so if you are on anticoagulant medication (like warfarin) or have a bleeding disorder, high doses of chamomile might increase bleeding risk.56  Otherwise, side effects are rare; occasionally some folks report drowsiness or upset stomach, but in clinical trials chamomile’s side effect profile was comparable to placebo.57 Chamomile is generally regarded as safe during pregnancy in moderation (it’s often used for pregnancy-related anxiety or insomnia), but because of its slight blood-thinning and uterine stimulant potential, it’s prudent to limit use in pregnancy and discuss with a doctor.58 

It’s definitely safer than many pharmaceuticals in that context, but caution is still advised. For most adults, chamomile is a gentle and agreeable ally for anxiety – a warm cup can truly calm the nerves.

 

Lavender doesn’t just smell lovely – studies show its scent and oral extracts can ease anxiety.


 What it is: Lavender is a fragrant purple-flowering plant famous for its use in aromatherapy. The essential oil of lavender has long been used for relaxation (in baths, diffusers, massage oils). More recently, oral capsules of a specific lavender oil preparation (known as Silexan) have been studied for anxiety relief. Lavender’s appeal is that it offers a natural, pleasant-smelling way to soothe nerves.

How it works: Lavender oil contains compounds (like linalool and linalyl acetate) that appear to interact with the brain’s serotonin (5-HT1A) receptors and modulate the GABA system.59  Inhaling lavender aroma can directly affect the limbic system (the emotional center) and reduce stress hormone levels. Oral lavender (Silexan) has been shown to influence neurotransmitters similarly to anxiolytic drugs, without causing sedation.60 

 Essentially, lavender has anxiolytic, mood-stabilizing, and even mild sedative effects, whether absorbed through smell or taken internally.

Evidence: The evidence for lavender in anxiety is quite robust, especially for the patented oral lavender oil Silexan. A 2019 meta-analysis of clinical trials found that Silexan (80 mg oral lavender oil capsules) significantly reduced anxiety symptoms in patients with subsyndromal anxiety and generalized anxiety disorder, compared to placebo.61 

 Impressively, lavender oil has been compared head-to-head with standard anti-anxiety medications in studies:

In one 6-week trial in GAD patients, Silexan (80 mg daily) was compared to 0.5 mg lorazepam. The result: lavender was just as effective as lorazepam in reducing anxiety, with HAM-A (anxiety scale) scores dropping ~45% in both groups.62  By the trial’s end, there was no statistical difference in anxiety reduction between lavender and the benzodiazepine. However, lavender had a big advantage – it did not cause sedation, cognitive impairment, or dependency, whereas 16% of the lorazepam group reported fatigue.63   Researchers concluded lavender is an effective and well-tolerated alternative to benzodiazepines for GAD.64  Another trial in 2014 compared Silexan to the antidepressant paroxetine for GAD and found lavender had comparable efficacy in reducing anxiety, with fewer side effects (and better improvement in co-occurring depression).65  Multiple placebo-controlled studies also show lavender oil significantly lowers anxiety symptoms and improves sleep quality relative to placebo.66  Notably, unlike many herbs, lavender’s effects can often be noticed within 1–2 weeks (some report better sleep and calmer mood in the first week of use). Lavender aromatherapy has also shown benefits: a systematic review found that inhaling lavender scent (via diffusers or sachets) significantly reduced anxiety levels in various settings, from dental offices to hospital rooms.67  In summary, lavender is one of the best-researched herbal anxiolytics, with evidence both for oral use and aromatherapy. It has demonstrated efficacy comparable to prescriptions in mild to moderate anxiety, minus heavy side effects. This makes it an attractive option for those seeking a gentle but effective approach.

butterfly on lavender

Typical usage: For aromatherapy, you can inhale lavender essential oil by using a diffuser, adding a few drops to a tissue and breathing it in, or using lavender-scented candles and sachets. This can be done as needed (e.g., at bedtime or during stressful moments). For oral use, the specific Silexan lavender oil capsule (80 mg once daily) is the form that has been tested in most studies. It’s available in some countries under names like Lavela WS 1265 or CalmAid. Typical dose is 80 mg lavender oil per day, taken with water. Some studies have explored 160 mg/day for severe anxiety. Do not ingest pure essential oil directly, as it’s highly concentrated – use prepared capsules or tinctures that are meant for oral use. As a calming tea, lavender is sometimes combined with chamomile or other herbs, but lavender tea alone is less common due to its strong flavor.

Safety: Lavender is generally very well tolerated. Aromatherapy: Inhaling lavender is quite safe for most; just ensure adequate ventilation and avoid direct contact with mucous membranes (it can irritate eyes, for example). Oral lavender: Silexan trials show a side effect rate similar to placebo. Mild GI symptoms can occur – some users report burping with a lavender aftertaste, or occasionally an upset stomach.68  A few individuals might get a mild headache. Unlike sedative drugs, oral lavender does not cause significant sedation; in fact, one reason it might improve sleep is by reducing anxiety rather than inducing drowsiness.69  One caution: children, especially young boys, should avoid consuming lavender oil, as there have been reports that topical lavender (in soaps or lotions) could have hormone-like effects (gynecomastia) in prepubertal boys.70 

This is rare and related to topical use, but out of caution, pediatric use of oral lavender isn’t recommended. For adults, there’s no evidence of hormonal disruption with oral capsules at the tested doses. Lavender is not known to interact seriously with medications, but theoretically, because it’s calming, it could add to the effects of other CNS depressants – so be mindful if combining it with sedatives or alcohol. As with most supplements, avoid in pregnancy due to limited research (although aromatherapy in moderation during pregnancy is generally considered safe). All in all, lavender offers a safe, pleasant way to find some calm – whether through its aroma or in capsule form.

 

Passionflower has striking blossoms and has been used traditionally to ease anxiety. 


 What it is: Passionflower is a climbing vine with exotic-looking purple and white flowers. Traditionally, Passiflora incarnata (maypop) has been used by Native Americans and in European herbalism for anxiety, insomnia, and even hysteria. The aerial parts (flowers, leaves, stems) are used to make teas, tinctures, or capsules. Passionflower is often combined with other calming herbs, but it has its own anxiolytic merits too.

How it works: Passionflower is thought to work by boosting GABA in the brain (similar to valerian). It likely increases GABA release or reuptake inhibition, thus providing a calming effect. Some studies suggest it may also bind to GABA_A receptors and modulate them. Additionally, passionflower might reduce the activity of certain brain enzymes that cause anxiety. The result is a mild sedative and anti-anxiety effect, helping to slow down racing thoughts and restlessness. It might also help with psychosomatic symptoms of anxiety (like muscle tension or gastrointestinal cramps) through its antispasmodic properties.

Evidence: While not as extensively researched as some others on this list, passionflower has some compelling clinical evidence. One landmark study from 2001 compared passionflower extract to a benzodiazepine in treating generalized anxiety disorder: In this double-blind trial, 36 outpatients with GAD were randomized to either Passiflora extract (45 drops/day of tincture) or oxazepam 30 mg/day for 4 weeks.71  The results were impressive – by the end of the study, passionflower was as effective as oxazepam in reducing overall anxiety symptoms, with no significant difference in outcomes between the herb and the drug.72  Oxazepam did work a bit faster in the first week, but by week 2-4 the efficacy was equivalent.73 Notably, the passionflower group had less impairment of job performance (daytime drowsiness) than the oxazepam group.74   In other words, passionflower didn’t cause the same level of sedation that the benzo did, allowing people to stay more alert. The study’s conclusion: “Passionflower extract is an effective drug for the management of generalized anxiety disorder, and the low incidence of impairment with passionflower compared to oxazepam is an advantage.75 

That’s high praise for a flower!

Other research includes a 2017 systematic review of passionflower in neuropsychiatric disorders, which found some evidence for its anxiety-reducing effects, including use as a pre-surgical anxiolytic.76   For instance, patients given passionflower before surgery had lower anxiety levels than those given placebo, without prolonging recovery time.77 

Many over-the-counter sleep and stress formulas include passionflower, supporting decades of anecdotal success in easing nervous tension and insomnia.

While more large-scale research would be helpful, existing studies and traditional use suggest passionflower can meaningfully reduce anxiety for some people – particularly situational anxiety or milder forms.

Typical dosage: Passionflower is often taken as a tincture or tea. For anxiety, a common dose is 10-30 drops of a passionflower tincture (1:5 herb:menstruum ratio) up to three times daily. In the GAD study, 45 drops/day of extract (split into two doses) was used.78 

As a tea, 1-2 grams of dried passionflower (about a heaping teaspoon) can be steeped in hot water for 10 minutes; drink 2-3 cups per day as needed. Capsules are available too, typically 250-500 mg of dried herb per dose, taken 2-3 times daily. Passionflower is sometimes combined with valerian or lemon balm at bedtime to synergistically improve sleep. If using a standalone supplement, start with a lower dose (e.g. 250 mg or 10 drops) to gauge your response, since some people may feel a bit sleepy with higher amounts.

Safety: Passionflower is generally considered safe and non-addictive when used in moderate doses. In studies, side effects were uncommon; however, it can cause drowsiness or dizziness in some individuals.79  Because of its mild sedative effect, caution is advised if you take it during the day – don’t drive or operate heavy machinery until you know how it affects you. It’s best used in the evening or when you have downtime. Passionflower can also potentially potentiate other sedatives (like kava, valerian, benzodiazepines, or alcohol), so avoid heavy combinations to prevent excessive sedation or confusion.80  Some users have reported mild gastrointestinal upset or nausea, but this is not common. There isn’t enough data on long-term use, so as with most calming herbs, it’s wise to take breaks (for instance, use it for a few weeks, then have a week off). Passionflower is not recommended for pregnant women, as it may stimulate uterine contractions. Also avoid if breastfeeding due to insufficient safety data. In the 2001 trial, no significant adverse effects or withdrawal symptoms were noted with abrupt cessation of passionflower after 4 weeks 81suggesting it doesn’t cause dependency. That said, if you’ve been taking it regularly for a long time, taper down to be gentle on your system. Overall, passionflower is a mild and natural way to ease anxiety – especially if you prefer something you can take in tea form or alongside other herbs – with a good safety profile for short-term use.

Comparing Natural Supplements with Prescription Medications for Anxiety

When considering natural supplements versus conventional anti-anxiety medications, it’s important to weigh their benefits and limitations:

Effectiveness: Prescription medications (like benzodiazepines such as Xanax or Ativan, and SSRIs/SNRIs like Zoloft or Effexor) are proven to be effective for anxiety disorders, often providing significant relief. Natural supplements tend to have milder effects. For instance, kava or lavender might reduce anxiety symptoms by a moderate amount,82 but they typically won’t eliminate severe anxiety or panic attacks as quickly as a benzodiazepine can. That said, some studies (as we saw with lavender and passionflower) show comparable efficacy to certain drugs in milder cases.83 

  • In general, if someone has mild to moderate anxiety, a supplement might be sufficient to take the edge off; for severe or debilitating anxiety, prescriptions or therapy are usually necessary.

Onset of action: Benzodiazepines have a rapid onset (30–60 minutes for acute anxiety relief), whereas many natural options take longer. Supplements like ashwagandha or magnesium often need days or weeks of consistent use to notice an effect.84  However, a few (like L-theanine or a lavender capsule) can work the same day for situational anxiety, just not as dramatically as a medication. If you need immediate, potent anxiety reduction (e.g., a panic attack), a prescribed med or fast-acting technique might be necessary; supplements are more for ongoing management or mild acute stress.

  • Side effect profile: This is where natural supplements shine. They tend to have fewer and gentler side effects than pharmaceuticals. For example, benzodiazepines can cause sedation, cognitive slowing, confusion, and are notorious for risk of dependence and withdrawal if used long-term. SSRIs can cause insomnia, sexual dysfunction, nausea, and initially even increased anxiety. In contrast, most herbal supplements have side effects that are relatively mild (if any) – maybe a bit of stomach upset, mild drowsiness, or headache. They are generally non-habit-forming. Someone is not going to get “addicted” to chamomile or passionflower, whereas relying on Xanax daily can lead to tolerance and dependency. No withdrawal syndromes are associated with stopping these herbs (aside from possibly rebound anxiety returning). This makes them appealing for long-term use. Moreover, natural products often have holistic benefits: for example, magnesium might improve sleep and muscle tension, and chamomile can aid digestion, whereas a medication might target anxiety but cause other discomforts.

  • Safety considerations: Prescription anxiety meds are regulated and quality-controlled; you know exactly what you’re getting in terms of dose. Supplements, on the other hand, are less tightly regulated by the FDA (in the U.S.) – product quality can vary. One brand’s “300 mg valerian” might differ from another’s in actual potency. There is also the risk of adulteration or contamination in poorly made supplements. Reputable brands and third-party testing are key to mitigate this. Medications typically go through rigorous testing for safety/efficacy, while supplements often rely on smaller studies. However, as discussed, many supplements have centuries of traditional use suggesting safety.

  • Dependency and long-term use: Most natural supplements do not carry a dependency risk, whereas medications like benzodiazepines can cause dependence in just a few weeks of daily use. This is a major advantage if you’re looking for something to use for months or years. You can drink chamomile tea every night for years without becoming “addicted” – you might become psychologically attached to the routine, but not physically dependent. With SSRIs, dependency isn’t the issue, but long-term use can lead to other side effects and requires tapering to discontinue due to withdrawal symptoms (antidepressant discontinuation syndrome). Supplements often allow more flexibility to start and stop with minimal fuss.

  • Holistic benefits: Natural remedies often align with a holistic approach – they might encourage a healthy ritual or lifestyle change. For example, making a nightly routine of tea and relaxation with lavender or chamomile can incorporate mindfulness and stress reduction beyond the herb itself. Many people appreciate that these supplements come directly from nature and can be part of a wellness lifestyle including diet, exercise, and mind-body techniques. Prescription meds, while extremely useful, are a targeted intervention and may not address underlying causes or come with any lifestyle component (in fact, one could argue they sometimes allow you to ignore lifestyle factors because the pill is doing the work).

  • Scientific certainty: It’s worth noting that the predictability of effect is higher with medications. Pharmaceutical doses are precise and effects are well-documented in large populations. Herbal supplements can have variability in constituents, and individuals may respond differently. One person might swear by 200 mg of L-theanine for social anxiety, another might feel nothing noticeable. With an SSRI, there’s a known percentage of responders and non-responders, and doctors can adjust strategy accordingly. So if someone needs a guaranteed strong anxiolytic effect, a prescription is the more reliable route. Supplements sometimes require a bit of personal trial and error to find what works.

In summary, natural supplements can be a great first approach or complementary approach for anxiety – especially for those with milder symptoms, those sensitive to medication side effects, or those who prefer a natural route. They tend to have fewer side effects and no addiction potential, which is a huge plus for long-term wellness. However, they might not be sufficient for everyone. Prescription medications have their place, particularly for moderate to severe anxiety or panic disorder, and can be life-changing for some individuals. It’s not necessarily an either/or decision: some people benefit from using these supplements alongside therapy or medications (with a doctor’s approval) to enhance overall anxiety control. Always tailor the approach to the individual – the “best” treatment is the one that safely and effectively helps you manage your anxiety and live a full life.

Safety Considerations and Contraindications

Before incorporating any natural supplement for anxiety, it’s crucial to keep safety in mind. “Natural” does not always mean “risk-free.” Here are general safety guidelines and potential contraindications for the supplements we’ve discussed:

Consult Your Healthcare Provider: If you are taking any prescription medications (especially for anxiety, depression, or other neurological conditions), talk to your doctor or pharmacist before starting a supplement. Many of these supplements act on the central nervous system and could have additive effects with pharmaceuticals. For example, combining multiple sedative substances (like valerian with a benzodiazepine, or kava with alcohol) can lead to excessive drowsiness or impairment.85 

  • Your provider can help prevent interactions or redundant therapies. This is particularly important if you are on blood thinners, thyroid medication, heart rhythm drugs, or anticonvulsants, as some supplements might affect these (e.g., chamomile with warfarin, ashwagandha with thyroid levels).

  • Pregnancy and Breastfeeding: Most anxiety supplements are not well-studied in pregnancy or lactation, so the cautious approach is to avoid them during this time. Chamomile and lavender in small culinary amounts (tea, aroma) are likely fine, but high-dose supplements should be skipped unless directed by a healthcare provider. Kava is contraindicated in pregnancy. Passionflower and valerian are also not recommended due to insufficient data and possible uterine effects. Always err on the side of caution for the baby’s safety.

Sedation and Operating Machinery: Some of these supplements can cause drowsiness or slow reaction time in certain individuals. For example, valerian and passionflower may relax you to the point of feeling sleepy or a bit groggy. Do not mix multiple sedative herbs together, and be careful about driving or operating heavy machinery, especially when you are first trying a supplement. See how it affects you on a day when you don’t have critical tasks. L-theanine, chamomile, and lavender are usually mild enough to not impair daytime function, but kava and valerian in particular should be treated with similar caution as you would a prescription anxiolytic in terms of activities requiring alertness.86  Allergies and Sensitivities: If you have plant allergies (like ragweed allergy in the case of chamomile), be mindful and possibly avoid that herb.87  Test with a small dose first. Some people might experience headaches or stomach upset from certain herbs – if so, discontinue use. Also, check the ingredient list of combination supplements to ensure they don’t contain something you’re allergic to (like a filler or another herb).

Shop for Vegan Protein

Shop Now
  • Quality of Supplements: Because supplements are not regulated as rigorously as drugs, choose high-quality brands. Look for products that are standardized to active constituents (e.g. “kavalactones 30%” or “ashwagandha root extract standardized to 5% withanolides”). Third-party certifications (USP, NSF, ConsumerLab) are a plus, as they indicate the product was tested for contaminants and accurate labeling. This is especially important for kava (due to liver safety – you want noble kava cultivars) and for any imported herbal products. Avoid buying obscure brands from questionable online marketplaces; stick to reputable health stores or brands with transparent testing.

     

Liver Health: Keep an eye on liver health if using supplements like kava or ashwagandha. Though liver injury is rare, it has occurred. Signs of trouble include yellowing of the skin/eyes, dark urine, severe fatigue, or upper right abdominal pain. If these occur, stop the supplement and get liver function tests. Do not take kava if you have a known liver condition. It’s also wise to limit duration of continuous kava use (e.g., use for a few weeks, then break for a week or two).88 

  • Ashwagandha’s liver incidents are very uncommon, but awareness is key – ensure any liver issues are evaluated.

     

Interactions with Medications: Each supplement has potential interactions. For instance, valerian can increase the sedative effect of sleep aids, barbiturates, and alcohol.89

  •  Chamomile might enhance anticoagulants or cause additive effects with other mild sedatives. Magnesium can interfere with absorption of certain medications if taken at the same time (like some antibiotics or thyroid hormone). St. John’s Wort (not covered above but often mentioned for mood) has extensive interactions – it can reduce effectiveness of birth control, antidepressants, etc., which exemplifies why checking for interactions is crucial. Always space out supplements and medications to avoid direct competition in absorption (e.g., take minerals like magnesium or calcium at least 2 hours apart from meds).

     

Underlying Health Conditions: If you have underlying health issues (like liver disease, kidney disease, low blood pressure, thyroid disorders, etc.), consider how a supplement might affect those. As noted, ashwagandha can influence thyroid hormone levels,90 so those with hyperthyroidism or on thyroid meds should be cautious. Magnesium can lower blood pressure slightly – good for most, but if you already have very low BP or are on hypertensive meds, monitor in case of additive effect. When in doubt, review your plan with a healthcare practitioner.

  • Not a Substitute for Professional Help: While natural supplements can be incredibly helpful, they should not replace therapy or medical treatment for significant anxiety disorders. If your anxiety is overwhelming, causing you to avoid activities, or leading to panic attacks, it’s important to consult a mental health professional. Supplements can be one tool in the toolkit – alongside lifestyle changes (exercise, diet, meditation) and possibly therapy (like CBT). There’s no shame in using medication if needed, either. Sometimes an integrative approach works best (for example, using an SSRI prescribed by your doctor and also drinking chamomile tea and practicing yoga). The goal is to relieve suffering and improve function. Use these natural tools as adjuncts or alternatives as appropriate, but keep your doctor informed so you have a comprehensive care plan.

In summary, the natural supplements discussed are generally safe for most people when used responsibly. Pay attention to your body’s responses, start with low doses, and maintain open communication with your healthcare provider. By doing so, you can minimize risks and reap the anxiety-reducing benefits of these remedies.

pharmacist Michael

Conclusion and Practical Advice

Managing anxiety often requires a holistic, personalized strategy. The natural supplements we’ve covered – ashwagandha, kava, L-theanine, valerian, chamomile, lavender, passionflower, and magnesium – all offer evidence-backed anxiolytic benefits that might help you find calmer days and better nights. They can be particularly useful for those with mild to moderate anxiety, stress-related anxiety, or as complementary aids alongside other treatments.

Practical tips for using these supplements:

  • Start Low and Go Slow: Introduce one supplement at a time, and start at the low end of the dose range to see how you respond. For example, try one cup of chamomile tea or 100 mg of L-theanine first, rather than multiple herbs or a high dose. This way, you can attribute any benefits or side effects to the correct substance. Titrate the dose up as needed over days or weeks.

Give it Time: Unlike a fast-acting anti-anxiety pill, supplements such as ashwagandha or magnesium may take a couple of weeks of consistent use to noticeably reduce anxiety.91 

  • Don’t give up after a day or two. Track your anxiety symptoms in a journal to see if there’s gradual improvement (sometimes the change is subtle). If nothing improves after, say, 4-6 weeks, then that particular supplement might not be effective for you.

  • Use Quality Products: As emphasized, choose reputable brands. It’s worth spending a little extra for a quality supplement than buying a cheap one that may be ineffective or impure. Read reviews, ask a pharmacist or naturopath for brand recommendations, and look for third-party testing. For herbal supplements, standardized extracts help ensure potency.

  • Lifestyle Matters: Remember that supplements are supplemental – they work best in the context of a healthy lifestyle. You can amplify their benefits by practicing relaxation techniques (deep breathing, meditation, yoga), maintaining a balanced diet, limiting stimulants like caffeine (which can counteract anti-anxiety efforts), and getting regular exercise (a natural anxiety reliever). For instance, magnesium will help more if you’re also not chronically sleep-deprived or nutritionally deficient. Think of these remedies as one part of your anxiety-management toolkit, which also includes psychological and behavioral strategies.

  • Monitor and Adjust: Pay attention to how you feel. If an herb isn’t helping or causes an unwanted side effect, you can stop it (most can be stopped without tapering). You might find one works wonderfully (e.g. lavender calms you a lot), whereas another does little – everyone’s body chemistry is different. It’s okay to try a different approach. Sometimes combining a couple of supplements in moderation works well (e.g. a cup of chamomile tea and 200 mg of L-theanine in the evening). Just avoid piling on too many sedative agents at once.

  • Know When to Seek Professional Help: When should you consult a healthcare professional? Certainly, if your anxiety is severe, persistent, or worsening despite self-care. If anxiety is interfering with your ability to work, socialize, or enjoy life, or if you experience panic attacks, it’s important to see a doctor or mental health specialist. Also, if you choose to use a natural supplement and you have any existing health conditions or take other medications, consulting a professional is advised to prevent interactions or complications. A doctor can also rule out medical causes of anxiety (like hyperthyroidism or vitamin B12 deficiency). Sometimes, starting therapy or medication to get anxiety under control may be necessary, and you can still use supplements as add-ons with guidance.

In conclusion, natural anxiety supplements can be valuable allies in your quest for calm. Scientific research backs their benefits, and many people have found relief using these gentle remedies. They offer a way to address anxiety with potentially fewer side effects and a more holistic touch. However, they are not magic bullets – results can vary, and they work best when combined with healthy habits and, when needed, professional guidance. Always listen to your body and do what’s best for your overall well-being. With the right plan in place – be it herbs, lifestyle changes, therapy, or a combination – you can tame anxiety and improve your quality of life. Here’s to finding your inner peace naturally!

 

Michael Brown in Lab Coat with arms crossed

Michael J. Brown, RPh, BCPS, BCPP

Mr. Brown is a Clinical Pharmacist specializing in pharmacotherapy and psychiatry.

Read Michael’s story here.

Feel free to send Michael a message using this link.

 

 
Pinterest Instagram Youtube

Disclosure:  This post may contain affiliate links, meaning, at no additional cost to you, I may earn a commission if you click on, or make a purchase through a third-party link.

  1. https://pubmed.ncbi.nlm.nih.gov/20929532/#:~:text=long,of%20adverse%20effects%20or%20withdrawal
  2. https://ods.od.nih.gov/factsheets/Ashwagandha-HealthProfessional/#:~:text=The%20species%20name%20somnifera%20comes,for%20stress%20and%20anxiety%20reduction
  3. https://ods.od.nih.gov/factsheets/Ashwagandha-HealthProfessional/#:~:text=cortisol%20levels,stronger%20recommendation%20without%20more%20data
  4. https://ods.od.nih.gov/factsheets/Ashwagandha-HealthProfessional/#:~:text=mg%2Fday%20of%20extract%20or%2012%2C000,mg%2Fday%20than%20with%20lower%20doses
  5. https://ods.od.nih.gov/factsheets/Ashwagandha-HealthProfessional/#:~:text=root%20powder%20made%20into%20granules,mg%2Fday%20than%20with%20lower%20doses
  6. https://ods.od.nih.gov/factsheets/Ashwagandha-HealthProfessional/#:~:text=Results%20from%20most%20of%20the,those%20in%20the%20placebo%20group
  7. https://ods.od.nih.gov/factsheets/Ashwagandha-HealthProfessional/#:~:text=Some%20research%20suggests%20that%20ashwagandha,83
  8. https://ods.od.nih.gov/factsheets/Ashwagandha-HealthProfessional/#:~:text=Ashwagandha%20appears%20to%20be%20well,sensitive%20prostate%20cancer
  9. https://ods.od.nih.gov/factsheets/Ashwagandha-HealthProfessional/#:~:text=There%20are%20a%20few%20reports,that%20contained%20450%20to%201%2C350
  10. https://ods.od.nih.gov/factsheets/Ashwagandha-HealthProfessional/#:~:text=Some%20research%20suggests%20that%20ashwagandha,83
  11. https://ods.od.nih.gov/factsheets/Ashwagandha-HealthProfessional/#:~:text=nausea%2C%20drowsiness%29%20are%20usually%20mild,sensitive%20prostate%20cancer
  12. https://ods.od.nih.gov/factsheets/Ashwagandha-HealthProfessional/#:~:text=ashwagandha%20extract%20,8%20%2C%2086
  13. https://www.aafp.org/pubs/afp/issues/2007/0815/p549.html#:~:text=Meta,weeks%20was%20safe%20and%20mildly
  14. https://www.aafp.org/pubs/afp/issues/2007/0815/p549.html#:~:text=Meta,4
  15. https://www.researchgate.net/figure/Meta-analysis-of-Hamilton-Anxiety-Rating-Scale-item-depressed-mood-intraindividual_fig1_359117234#:~:text=Meta,
  16. https://www.aafp.org/pubs/afp/issues/2007/0815/p549.html#:~:text=Meta,weeks%20was%20safe%20and%20mildly
  17. https://www.aafp.org/pubs/afp/issues/2007/0815/p549.html#:~:text=only%203,allowed%20more%20comparisons%20between%20patient
  18. https://pubmed.ncbi.nlm.nih.gov/19962288/#:~:text=investigated%20in%20adults%20with%20GAD,A%20subscore%20I%29%20and%20%22psychic
  19. https://pubmed.ncbi.nlm.nih.gov/19962288/#:~:text=adults%20with%20GAD,and%20well%20tolerated%20alternative%20to
  20. https://www.researchgate.net/publication/10944828_Kava_extract_for_treating_anxiety_Cochrane_Review#:~:text=Kava%20extract%20for%20treating%20anxiety,24%5D%20.%20A
  21. https://www.drugs.com/npp/kava.html#:~:text=Kava%20Uses%2C%20Benefits%20%26%20Dosage,and%20use%20is%20not%20recommended
  22. https://www.aafp.org/pubs/afp/issues/2007/0815/p549.html#:~:text=Researchers%20concluded%20that%20liver%20toxicity,toxicity%20have%20been%20reported%2C%20some
  23. https://www.aafp.org/pubs/afp/issues/2007/0815/p549.html#:~:text=Kava%20dramatically%20inhibits%20the%20cytochrome,used%20by%20the%20liver%20to
  24. https://www.aafp.org/pubs/afp/issues/2007/0815/p549.html#:~:text=only%203,allowed%20more%20comparisons%20between%20patient
  25. https://www.aafp.org/pubs/afp/issues/2007/0815/p549.html#:~:text=Kava%20dramatically%20inhibits%20the%20cytochrome,used%20by%20the%20liver%20to
  26. https://www.sciencedirect.com/science/article/abs/pii/S1043661819307790#:~:text=Psychotropic%20effects%20of%20L,reducing%20effects
  27. https://www.healthline.com/health/l-theanine#:~:text=Healthline%20www,16
  28. https://doi.org/10.3390/nu11102362#:~:text=functions,functions%20simultaneously%20in%20healthy%20adults
  29. https://link.springer.com/article/10.1007/s40120-021-00284-x#:~:text=A%20Randomized%2C%20Triple,anxiety%20compared%20to%20the
  30. https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-024-06285-y#:~:text=match%20at%20L629%20LT%20did,to%20better%20understand%20its%20benefits
  31. https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-024-06285-y#:~:text=symptoms%20effectively%2C%20notably%20in%20individuals,was%20not%20consistent%20across%20all
  32. https://www.sciencedirect.com/science/article/abs/pii/S1043661819307790#:~:text=Psychotropic%20effects%20of%20L,improvements%20in%20other%20manifestations
  33. https://www.healthycell.com/blogs/articles/what-is-the-best-dosage-for-l-theanine?srsltid=AfmBOordVGS45Yh7XVBVo0zT3BFDDqlzVKlCPjl04AKH8wilkjOP66aD#:~:text=What%20is%20the%20best%20dosage,can%20also%20cause%20side%20effects
  34. https://www.webmd.com/vitamins/ai/ingredientmono-1053/theanine#:~:text=Theanine%20,
  35. https://www.mountsinai.org/health-library/herb/valerian#:~:text=helps%20regulate%20nerve%20cells%20and,a%20similar%2C%20but%20weaker%20effect
  36. https://www.mountsinai.org/health-library/herb/valerian#:~:text=helps%20regulate%20nerve%20cells%20and,a%20similar%2C%20but%20weaker%20effect
  37. https://www.sciencedirect.com/science/article/abs/pii/S0944711309002906#:~:text=Valeriana%20officinalis%20root%20extracts%20have,compared%20to%20the%20ethanol
  38. https://www.cochrane.org/CD004515/DEPRESSN_valerian-for-anxiety-disorders#:~:text=Only%20one%20study%20was%20identified%2C,treatment%20option%20for%20anxiety%20disorders
  39. https://www.cochrane.org/CD004515/DEPRESSN_valerian-for-anxiety-disorders#:~:text=Authors%27%20conclusions%3A
  40. https://pmc.ncbi.nlm.nih.gov/articles/PMC4394901/#:~:text=Valerian%20for%20Sleep%3A%20A%20Systematic,range%20of%20doses%20of
  41. https://www.mountsinai.org/health-library/herb/valerian#:~:text=pregnant%20and%20nursing%20women%20to,avoid%20taking%20valerian
  42. https://www.mountsinai.org/health-library/herb/valerian#:~:text=Some%20people%20may%20have%20a,instead%20of%20calm%20and%20sleepy
  43. https://www.mountsinai.org/health-library/herb/valerian#:~:text=For%20most%20people%2C%20valerian%20does,than%20stopping%20all%20at%20once
  44. https://www.mountsinai.org/health-library/herb/valerian#:~:text=things%20that%20require%20you%20to,be%20alert
  45. https://www.mountsinai.org/health-library/herb/valerian#:~:text=The%20same%20is%20true%20of,chamomile%2C%20lemon%20balm%2C%20and%20catnip
  46.   https://www.mountsinai.org/health-library/herb/valerian#:~:text=Because%20valerian%20is%20broken%20down,not%20limited%20to%20the%20following
  47. https://www.mountsinai.org/health-library/herb/valerian#:~:text=Anesthesia
  48. https://www.mayoclinic.org/diseases-conditions/generalized-anxiety-disorder/expert-answers/herbal-treatment-for-anxiety/faq-20057945#:~:text=sleepiness.%20,if%20you%27re%20pregnant%20or%20breastfeeding
  49. https://pubmed.ncbi.nlm.nih.gov/19593179/#:~:text=Results%3A%20%20We%20observed%20a,417
  50. https://pubmed.ncbi.nlm.nih.gov/19593179/#:~:text=Results%3A%20%20We%20observed%20a,417
  51. https://pubmed.ncbi.nlm.nih.gov/19593179/#:~:text=Conclusions%3A%20%20This%20is%20the,needed%20to%20replicate%20these%20observations
  52. https://pubmed.ncbi.nlm.nih.gov/19593179/#:~:text=was%20not%20powered%20to%20identify,417
  53. https://pubmed.ncbi.nlm.nih.gov/27912875/#:~:text=Long,significantly%20reduce%20rate%20of%20relapse
  54. https://www.mdedge9-ma1.mdedge.com/clinicianreviews/article/166955/mental-health/evidence-herbal-and-botanical-remedies-part-2/page/0/2#:~:text=Insomnia,28
  55. https://www.mayoclinic.org/diseases-conditions/generalized-anxiety-disorder/expert-answers/herbal-treatment-for-anxiety/faq-20057945#:~:text=sleepiness.%20,if%20you%27re%20pregnant%20or%20breastfeeding
  56. https://www.mayoclinic.org/diseases-conditions/generalized-anxiety-disorder/expert-answers/herbal-treatment-for-anxiety/faq-20057945#:~:text=sleepiness.%20,if%20you%27re%20pregnant%20or%20breastfeeding
  57. https://www.mdedge9-ma1.mdedge.com/clinicianreviews/article/166955/mental-health/evidence-herbal-and-botanical-remedies-part-2/page/0/2#:~:text=
  58. https://www.mayoclinic.org/diseases-conditions/generalized-anxiety-disorder/expert-answers/herbal-treatment-for-anxiety/faq-20057945#:~:text=sleepiness.%20,if%20you%27re%20pregnant%20or%20breastfeeding
  59. https://pmc.ncbi.nlm.nih.gov/articles/PMC4360214/#:~:text=,DPAT%20in%20this
  60. https://link.springer.com/article/10.1007/s00406-024-01923-8#:~:text=Silexan%20may%20indirectly%20elevate%20extracellular,effects%20on%20other%20brain%20regions
  61. https://www.sciencedirect.com/science/article/pii/S0944711319303411#:~:text=reduce%20anxiety%20levels%20measured%20with,95
  62. https://pubmed.ncbi.nlm.nih.gov/19962288/#:~:text=investigated%20in%20adults%20with%20GAD,A%20subscore%20I%29%20and%20%22psychic
  63. https://pubmed.ncbi.nlm.nih.gov/19962288/#:~:text=diary%20demonstrated%20comparable%20positive%20effects,and%20well%20tolerated%20alternative%20to
  64. https://pubmed.ncbi.nlm.nih.gov/19962288/#:~:text=SF%2036%20Health%20survey%20Questionnaire,for%20amelioration%20of%20generalised%20anxiety
  65. https://www.researchgate.net/publication/40449277_A_multi-center_double-blind_randomised_study_of_the_Lavender_oil_preparation_Silexan_in_comparison_to_Lorazepam_for_generalized_anxiety_disorder#:~:text=A%20multi,2014
  66. https://www.sciencedirect.com/science/article/abs/pii/S0022395618310999#:~:text=Beneficial%20effects%20of%20Silexan%20on,action%20rather%20than%20by%20sedation
  67. https://www.sciencedirect.com/science/article/pii/S0944711319303411#:~:text=analysis%20www,95
  68. https://www.mayoclinic.org/diseases-conditions/generalized-anxiety-disorder/expert-answers/herbal-treatment-for-anxiety/faq-20057945#:~:text=members%20of%20this%20family%20are,so%20do%20not%20use%20it
  69. https://www.sciencedirect.com/science/article/abs/pii/S0022395618310999#:~:text=The%20results%20indicate%20that%20Silexan,action%20rather%20than%20by%20sedation
  70. https://www.mayoclinic.org/diseases-conditions/generalized-anxiety-disorder/expert-answers/herbal-treatment-for-anxiety/faq-20057945#:~:text=,so%20do%20not%20use%20it
  71. https://pubmed.ncbi.nlm.nih.gov/11679026/#:~:text=Results%3A%20%20Passiflora%20extract%20and,encountered%20with%20subjects%20on%20oxazepam
  72. https://pubmed.ncbi.nlm.nih.gov/11679026/#:~:text=Results%3A%20%20Passiflora%20extract%20and,encountered%20with%20subjects%20on%20oxazepam.
  73. https://www.mountsinai.org/health-library/herb/passionflower?insider=m0ry-tracey-carlson#:~:text=Studies%20of%20people%20with%20generalized,from%20anesthesia%20just%20as%20quickly
  74. https://pubmed.ncbi.nlm.nih.gov/11679026/#:~:text=generalized%20anxiety%20disorder,encountered%20with%20subjects%20on%20oxazepam
  75. https://pubmed.ncbi.nlm.nih.gov/11679026/#:~:text=Conclusion%3A%20%20The%20results%20suggest,scale%20trial%20is%20justified
  76. https://www.mountsinai.org/health-library/herb/passionflower?insider=m0ry-tracey-carlson#:~:text=Studies%20of%20people%20with%20generalized,from%20anesthesia%20just%20as%20quickly
  77. https://www.mountsinai.org/health-library/herb/passionflower?insider=m0ry-tracey-carlson#:~:text=tell%20what%20effects%20passionflower%20has,on%20its%20own
  78. https://pubmed.ncbi.nlm.nih.gov/11679026/#:~:text=Methods%3A%20%20The%20study%20was,week%20trial
  79. https://www.mountsinai.org/health-library/herb/passionflower?insider=m0ry-tracey-carlson#:~:text=didn%27t%20work%20as%20quickly%20as,from%20anesthesia%20just%20as%20quickly
  80. https://www.mountsinai.org/health-library/herb/passionflower?insider=m0ry-tracey-carlson#:~:text=Plant%20Description
  81. https://pubmed.ncbi.nlm.nih.gov/11679026/#:~:text=Conclusion%3A%20%20The%20results%20suggest,scale%20trial%20is%20justified
  82. https://consensus.app/questions/does-kava-reduce-anxity/#:~:text=other%20studies%20highlight%20potential%20side,as%20liver%20toxicity%20and
  83. https://pubmed.ncbi.nlm.nih.gov/11679026/#:~:text=Results%3A%20%20Passiflora%20extract%20and,encountered%20with%20subjects%20on%20oxazepam
  84. https://ods.od.nih.gov/factsheets/Ashwagandha-HealthProfessional/#:~:text=root%20powder%20made%20into%20granules,mg%2Fday%20than%20with%20lower%20doses
  85. https://www.mountsinai.org/health-library/herb/passionflower?insider=m0ry-tracey-carlson#:~:text=Studies%20of%20people%20with%20generalized,from%20anesthesia%20just%20as%20quickly
  86. https://www.mountsinai.org/health-library/herb/valerian#:~:text=Don%27t%20use%20valerian%20while%20driving%2C,require%20you%20to%20be%20alert
  87. https://www.mayoclinic.org/diseases-conditions/generalized-anxiety-disorder/expert-answers/herbal-treatment-for-anxiety/faq-20057945#:~:text=sleepiness.%20,if%20you%27re%20pregnant%20or%20breastfeeding
  88. https://www.aafp.org/pubs/afp/issues/2007/0815/p549.html#:~:text=Researchers%20concluded%20that%20liver%20toxicity,toxicity%20have%20been%20reported%2C%20some
  89. https://www.mountsinai.org/health-library/herb/valerian#:~:text=Sedatives
  90. https://ods.od.nih.gov/factsheets/Ashwagandha-HealthProfessional/#:~:text=Some%20research%20suggests%20that%20ashwagandha,83
  91. https://pubmed.ncbi.nlm.nih.gov/28445426/#:~:text=Results%3A%20%2018%20studies%20were,subjective%20stress%20as%20an%20outcome

Leave a Comment

Scroll to Top
[]
×
Why Choose to Autoship?
  • Automatically re-order your favorite products on your schedule.
  • Easily change the products or shipping date for your upcoming Scheduled Orders.
  • Pause or cancel any time.

Autoship powered by